학술논문

Linking enlarged choroid plexus with plasma analyte and structural phenotypes in clinical high risk for psychosis: A multisite neuroimaging study.
Document Type
Academic Journal
Author
Bannai D; Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA.; Reuter M; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany; A.A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, USA; Department of Radiology, Harvard Medical School, Boston, MA, USA.; Hegde R; Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA.; Hoang D; Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA.; Adhan I; Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA.; Gandu S; Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA.; Pong S; Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA.; Raymond N; Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA.; Zeng V; Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA.; Chung Y; Department of Psychology, Yale University, New Haven, CT, USA.; He G; Department of Psychology, Yale University, New Haven, CT, USA.; Sun D; Semel Institute for Neuroscience and Human Behavior and Department of Psychology, UCLA, Los Angeles, CA, USA.; van Erp TGM; Clinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, UC Irvine, Irvine, CA, USA.; Addington J; Hotchkins Brain Institute, Department of Psychiatry, University of Calgary, Calgary, AB, Canada.; Bearden CE; Semel Institute for Neuroscience and Human Behavior and Department of Psychology, UCLA, Los Angeles, CA, USA.; Cadenhead K; Department of Psychiatry, UCSD, San Diego, CA, USA.; Cornblatt B; Department of Psychiatry, Zucker Hillside Hospital, Queens, NY, USA.; Mathalon DH; Department of Psychiatry, UCSF, San Francisco, CA, USA.; McGlashan T; Department of Psychiatry, Yale University, New Haven, CT, USA.; Jeffries C; Renaissance Computing Institute, University of North Carolina, Chapel Hill, NC, USA.; Stone W; Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Tsuang M; Department of Psychiatry, UCSD, San Diego, CA, USA.; Walker E; Department of Psychology, Yale University, New Haven, CT, USA.; Woods SW; Department of Psychiatry, Yale University, New Haven, CT, USA.; Cannon TD; Department of Psychology, Yale University, New Haven, CT, USA; Department of Psychiatry, Yale University, New Haven, CT, USA.; Perkins D; Renaissance Computing Institute, University of North Carolina, Chapel Hill, NC, USA; Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA.; Keshavan M; Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Lizano P; Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA; Division of Translational Neuroscience, Beth Israel Deaconess Medical Center, Boston, MA, USA. Electronic address: lizanopl@gmail.com.
Source
Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8800478 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2139 (Electronic) Linking ISSN: 08891591 NLM ISO Abbreviation: Brain Behav Immun Subsets: MEDLINE
Subject
Language
English
Abstract
Background: Choroid plexus (ChP) enlargement exists in first-episode and chronic psychosis, but whether enlargement occurs before psychosis onset is unknown. This study investigated whether ChP volume is enlarged in individuals with clinical high-risk (CHR) for psychosis and whether these changes are related to clinical, neuroanatomical, and plasma analytes.
Methods: Clinical and neuroimaging data from the North American Prodrome Longitudinal Study 2 (NAPLS2) was used for analysis. 509 participants (169 controls, 340 CHR) were recruited. Conversion status was determined after 2-years of follow-up, with 36 psychosis converters. The lateral ventricle ChP was manually segmented from baseline scans. A subsample of 31 controls and 53 CHR had plasma analyte and neuroimaging data.
Results: Compared to controls, CHR (d = 0.23, p = 0.017) and non-converters (d = 0.22, p = 0.03) demonstrated higher ChP volumes, but not in converters. In CHR, greater ChP volume correlated with lower cortical (r = -0.22, p < 0.001), subcortical gray matter (r = -0.21, p < 0.001), and total white matter volume (r = -0.28,p < 0.001), as well as larger lateral ventricle volume (r = 0.63,p < 0.001). Greater ChP volume correlated with makers functionally associated with the lateral ventricle ChP in CHR [CCL1 (r = -0.30, p = 0.035), ICAM1 (r = 0.33, p = 0.02)], converters [IL1β (r = 0.66, p = 0.004)], and non-converters [BMP6 (r = -0.96, p < 0.001), CALB1 (r = -0.98, p < 0.001), ICAM1 (r = 0.80, p = 0.003), SELE (r = 0.59, p = 0.026), SHBG (r = 0.99, p < 0.001), TNFRSF10C (r = 0.78, p = 0.001)].
Conclusions: CHR and non-converters demonstrated significantly larger ChP volumes compared to controls. Enlarged ChP was associated with neuroanatomical alterations and analyte markers functionally associated with the ChP. These findings suggest that the ChP may be a key an important biomarker in CHR.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier Inc. All rights reserved.)