학술논문

Pancreatic neuroendocrine neoplasms - update of the diagnostic and therapeutic guidelines (recommended by the Polish Network of Neuroendocrine Tumours) [Nowotwory neuroendokrynne trzustki - uaktualnione zasady diagnostyki i leczenia (rekomendowane przez Polską Sieć Guzów Neuroendokrynych)].
Document Type
Academic Journal
Author
Kos-Kudła B; Department of Endocrinology and Neuroendocrine Tumours, Department of Pathophysiology and Endocrinology, Medical University of Silesia, Katowice, Poland.; Rosiek V; Department of Endocrinology and Neuroendocrine Tumours, Department of Pathophysiology and Endocrinology, Medical University of Silesia, Katowice, Poland.; Borowska M; Department of Endocrinology and Neuroendocrine Tumours, Medical University of Silesia, Katowice, Poland.; Bednarczuk T; Department of Internal Medicine and Endocrinology, Medical University of Warsaw, Warsaw, Poland.; Bolanowski M; Chair and Department of Endocrinology, Diabetes, and Isotope Therapy, Medical University of Wroclaw, Wroclaw, Poland.; Chmielik E; Tumor Pathology Department, Maria Sklodowska-Curie Memorial National Research Institute of Oncology, Gliwice Branch, Gliwice, Poland.; Ćwikła JB; Department of Cardiology and Internal Medicine, Collegium Medicum, University of Warmia and Mazury, Olsztyn, Poland.; Foltyn W; Department of Endocrinology and Neuroendocrine Tumours, Department of Pathophysiology and Endocrinology, Medical University of Silesia, Katowice, Poland. wandafoltyn@poczta.onet.pl.; Gisterek I; Chair of Oncology and Radiotherapy, Medical University of Silesia, Katowice, Poland.; Handkiewicz-Junak D; Department of Nuclear Medicine and Endocrine Oncology, Maria Sklodowska-Curie Memorial National Research Institute of Oncology, Gliwice Brench, Gliwice, Poland.; Hubalewska-Dydejczyk A; Chair and Department of Endocrinology, Jagiellonian University Medical College, Cracow, Poland.; Jarząb M; Breast Unit, Maria Sklodowska-Curie Memorial National Research Institute of Oncology, Gliwice Branch, Gliwice, Poland.; Junik R; Department of Endocrinology and Diabetology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Bydgoszcz, Poland.; Kajdaniuk D; Division of Pathophysiology, Department of Pathophysiology and Endocrinology, Medical University of Silesia, Katowice, Poland.; Kamiński G; Department of Endocrinology and Radioisotope Therapy, Military Institute of Medicine, Warsaw, Poland.; Kolasińska-Ćwikła A; Department of Oncology and Radiotherapy, Maria Sklodowska-Curie Memorial National Research Institute of Oncology, Warsaw, Poland.; Kowalska A; Department of Endocrinology, Holycross Cancer Centre, Collegium Medicum, Jan Kochanowski University, Kielce, Poland.; Królicki L; Nuclear Medicine Department, Medical University of Warsaw, Warsaw, Poland.; Kunikowska J; Nuclear Medicine Department, Medical University of Warsaw, Warsaw, Poland.; Kuśnierz K; Department of Gastrointestinal Surgery, Medical University of Silesia, Katowice, Poland.; Lewiński A; Department of Endocrinology and Metabolic Diseases, Medical University of Lodz, Lodz, Poland.; Liszka Ł; Department of Pathomorphology and Molecular Diagnostics, Medical University of Silesia, Katowice, Poland.; Londzin-Olesik M; Department of Endocrinology and Neuroendocrine Tumours, Department of Pathophysiology and Endocrinology, Medical University of Silesia, Katowice, Poland.; Marek B; Division of Pathophysiology, Department of Pathophysiology and Endocrinology, Medical University of Silesia, Katowice, Poland.; Malczewska A; Department of Endocrinology and Neuroendocrine Tumours, Department of Pathophysiology and Endocrinology, Medical University of Silesia, Katowice, Poland.; Nasierowska-Guttmejer A; Faculty of Medicine, Lazarski University in Warsaw, Warsaw, Poland.; Nowakowska-Duława E; Department of Gastroenterology and Hepatology, Medical University of Silesia, Katowice, Poland.; Pavel ME; Department of Medicine 1, Endocrinology and Diabetology, Friedrich Alexander University of Erlangen-Nürnberg, Erlangen, Germany.; Pilch-Kowalczyk J; Department of Radiology and Nuclear Medicine, Medical University of Silesia, Katowice, Poland.; Reguła J; Department of Oncological Gastroenterology, Maria Sklodowska-Curie Memorial National Research Institute of Oncology, Warsaw, Poland.; Ruchała M; Department of Endocrinology, Metabolism and Internal Diseases, Medical University in Poznan, Poznan, Poland.; Rydzewska G; Department of Internal Medicine and Gastroenterology, Central Clinical Hospital of the Ministry of Interior and Administration, Warsaw, Poland.; Siemińska L; Division of Pathophysiology, Department of Pathophysiology and Endocrinology, Medical University of Silesia, Katowice, Poland.; Sowa-Staszczak A; Chair and Department of Endocrinology, Jagiellonian University Medical College, Cracow, Poland.; Starzyńska T; Department of Gastroenterology, Medical Pomeranian University in Szczecin, Szczecin, Poland.; Stojčev Z; Department of Oncology and Breast Diseases, Centre of Postgraduate Medical Education, Warsaw, Poland.; Strzelczyk J; Department of Endocrinology and Neuroendocrine Tumours, Department of Pathophysiology and Endocrinology, Medical University of Silesia, Katowice, Poland.; Studniarek M; Department of Radiology, Medical University of Gdansk, Gdansk, Poland.; Syrenicz A; Department of Endocrinology, Metabolic and Internal Diseases, Pomeranian Medical University, Szczecin, Poland.; Szczepkowski M; Clinical Department of Colorectal, General and Oncological Surgery, Centre of Postgraduate Medical Education, Warsaw, Poland.; Wachuła E; Department of Clinical Oncology, Gdynia Oncology Centre of the Polish Red Cross Maritime Hospital, Gdynia, Poland.; Zajęcki W; Department of Endocrinology and Neuroendocrine Tumours, Medical University of Silesia, Katowice, Poland.; Zemczak A; Department of Endocrinology and Neuroendocrine Tumours, Department of Pathophysiology and Endocrinology, Medical University of Silesia, Katowice, Poland.; Zgliczyński W; Department of Endocrinology, Centre of Postgraduate Medical Education, Warsaw, Poland.; Zieniewicz K; Chair and Department of General, Transplant, and Liver Surgery, Medical University of Warsaw, Warsaw, Poland.
Source
Publisher: Via Medica Country of Publication: Poland NLM ID: 0370674 Publication Model: Print Cited Medium: Internet ISSN: 2299-8306 (Electronic) Linking ISSN: 0423104X NLM ISO Abbreviation: Endokrynol Pol Subsets: MEDLINE
Subject
Language
English
Abstract
In this paper, we present the current guidelines for the diagnostics and management of pancreatic neuroendocrine neoplasms (PanNENs) developed by Polish experts providing care for these patients in everyday clinical practice. In oncological diagnostics, in addition to biochemical tests, molecular identification with the use of NETest liquid biopsy and circulating microRNAs is gaining importance. Both anatomical and functional examinations (including new radiopharmaceuticals) are used in imaging diagnostics. Histopathological diagnosis along with immunohistochemical examination still constitute the basis for therapeutic decisions. Whenever possible, surgical procedure is the treatment of choice. Pharmacological management including biotherapy, radioisotope therapy, targeted molecular therapy and chemotherapy are important methods of systemic therapy. Treatment of PanNENs requires a multidisciplinary team of specialists in the field of neuroendocrine neoplasms.