학술논문
Oral and gut microbial profiling in periodontitis and Parkinson's disease.
Document Type
Academic Journal
Author
Yay E; Department of Applied Oral Sciences, The ADA Forsyth Institute, Cambridge, MA, USA.; Periodontist, Private Practice, Istanbul, Turkey.; Yilmaz M; Department of Applied Oral Sciences, The ADA Forsyth Institute, Cambridge, MA, USA.; Department of Periodontology, Istanbul Medipol University, Istanbul, Turkey.; Toygar H; Department of Periodontology, Istanbul Medipol University, Istanbul, Turkey.; Balci N; Department of Periodontology, Istanbul Medipol University, Istanbul, Turkey.; Alvarez Rivas C; Department of Applied Oral Sciences, The ADA Forsyth Institute, Cambridge, MA, USA.; Department of Oral Microbiology and Infection, Harvard School of Dental Medicine, Boston, MA, USA.; Bolluk Kılıç B; Department of Neurology, Istanbul Medipol University, Istanbul, Turkey.; Zirh A; Department of Neurology, Istanbul Medipol University, Istanbul, Turkey.; Paster BJ; Department of Applied Oral Sciences, The ADA Forsyth Institute, Cambridge, MA, USA.; Department of Oral Microbiology and Infection, Harvard School of Dental Medicine, Boston, MA, USA.; Kantarci A; Department of Applied Oral Sciences, The ADA Forsyth Institute, Cambridge, MA, USA.; Department of Oral Microbiology and Infection, Harvard School of Dental Medicine, Boston, MA, USA.
Source
Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101551049 Publication Model: eCollection Cited Medium: Print ISSN: 2000-2297 (Print) Linking ISSN: 20002297 NLM ISO Abbreviation: J Oral Microbiol Subsets: PubMed not MEDLINE
Subject
Language
English
ISSN
2000-2297
Abstract
Objectives: We tested the hypothesis that Parkinson's disease (PA) alters the periodontitis-associated oral microbiome.
Method: Patients with periodontitis with Parkinson's disease (PA+P) and without PA (P) and systemically and periodontally healthy individuals (HC) were enrolled. Clinical, periodontal and neurological parameters were recorded. The severity of PA motor functions was measured. Unstimulated saliva samples and stool samples were collected. Next-generation sequencing of 16S ribosomal RNA (V1-V3 regions) was performed.
Results: PA patients had mild-to-moderate motor dysfunction and comparable plaque scores as those without, indicating that oral hygiene was efficient in the PA+P group. In saliva, there were statistically significant differences in beta diversity between HC and PA+P (p = 0.001), HC and P (p = 0.001), and P and PA+P (p = 0.028). The microbial profiles of saliva and fecal samples were distinct. Mycoplasma faucium, Tannerella forsythia, Parvimonas micra, and Saccharibacteria (TM7) were increased in P; Prevotella pallens, Prevotella melaninogenica, Neisseria multispecies were more abundant in PA+P group, Ruthenibacterium lactatiformans, Dialister succinatiphilus, Butyrivibrio crossotus and Alloprevotella tannerae were detected in fecal samples in P groups compared to healthy controls.
Conclusions: No significant differences were detected between Parkinson's and non-Parkinson's gut microbiomes, suggesting that Parkinson's disease modifies the oral microbiome in periodontitis subjects independent of the gut microbiome.
Competing Interests: No potential conflict of interest was reported by the author(s).
(© 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.)
Method: Patients with periodontitis with Parkinson's disease (PA+P) and without PA (P) and systemically and periodontally healthy individuals (HC) were enrolled. Clinical, periodontal and neurological parameters were recorded. The severity of PA motor functions was measured. Unstimulated saliva samples and stool samples were collected. Next-generation sequencing of 16S ribosomal RNA (V1-V3 regions) was performed.
Results: PA patients had mild-to-moderate motor dysfunction and comparable plaque scores as those without, indicating that oral hygiene was efficient in the PA+P group. In saliva, there were statistically significant differences in beta diversity between HC and PA+P (p = 0.001), HC and P (p = 0.001), and P and PA+P (p = 0.028). The microbial profiles of saliva and fecal samples were distinct. Mycoplasma faucium, Tannerella forsythia, Parvimonas micra, and Saccharibacteria (TM7) were increased in P; Prevotella pallens, Prevotella melaninogenica, Neisseria multispecies were more abundant in PA+P group, Ruthenibacterium lactatiformans, Dialister succinatiphilus, Butyrivibrio crossotus and Alloprevotella tannerae were detected in fecal samples in P groups compared to healthy controls.
Conclusions: No significant differences were detected between Parkinson's and non-Parkinson's gut microbiomes, suggesting that Parkinson's disease modifies the oral microbiome in periodontitis subjects independent of the gut microbiome.
Competing Interests: No potential conflict of interest was reported by the author(s).
(© 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.)