학술논문
Periodontitis and brain magnetic resonance imaging markers of Alzheimer's disease and cognitive aging.
Document Type
Academic Journal
Author
Rubinstein T; Division of Periodontics, Section of Oral, Diagnostic and Rehabilitation Sciences, College of Dental Medicine, New York, New York, USA.; Brickman AM; Department of Neurology, Vagelos College of Physicians and Surgeons, New York, New York, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain and Gertrude H. Sergievsky Center, New York, New York, USA.; Cheng B; Department of Biostatistics, Mailman School of Public Health, New York, New York, USA.; Burkett S; Division of Periodontics, Section of Oral, Diagnostic and Rehabilitation Sciences, College of Dental Medicine, New York, New York, USA.; Park H; Division of Infectious Diseases, Department of Medicine, Vagelos College of Physicians and, Surgeons, Irving Medical Center, Columbia University, New York, New York, USA.; Annavajhala MK; Division of Infectious Diseases, Department of Medicine, Vagelos College of Physicians and, Surgeons, Irving Medical Center, Columbia University, New York, New York, USA.; Uhlemann AC; Division of Infectious Diseases, Department of Medicine, Vagelos College of Physicians and, Surgeons, Irving Medical Center, Columbia University, New York, New York, USA.; Andrews H; Department of Biostatistics, Mailman School of Public Health, New York, New York, USA.; Gutierrez J; Department of Neurology, Vagelos College of Physicians and Surgeons, New York, New York, USA.; Paster BJ; The Forsyth Institute, Cambridge, Massachusetts, USA.; Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts, USA.; Noble JM; Department of Neurology, Vagelos College of Physicians and Surgeons, New York, New York, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain and Gertrude H. Sergievsky Center, New York, New York, USA.; Papapanou PN; Division of Periodontics, Section of Oral, Diagnostic and Rehabilitation Sciences, College of Dental Medicine, New York, New York, USA.
Source
Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE
Subject
Language
English
Abstract
Introduction: We examined the association of clinical, microbiological, and host response features of periodontitis with MRI markers of atrophy/cerebrovascular disease in the Washington Heights Inwood Columbia Aging Project (WHICAP) Ancillary Study of Oral Health.
Methods: We analyzed 468 participants with clinical periodontal data, microbial plaque and serum samples, and brain MRIs. We tested the association of periodontitis features with MRI features, after adjusting for multiple risk factors for Alzheimer's disease/Alzheimer's disease-related dementia (AD/ADRD).
Results: In fully adjusted models, having more teeth was associated with lower odds for infarcts, lower white matter hyperintensity (WMH) volume, higher entorhinal cortex volume, and higher cortical thickness. Higher extent of periodontitis was associated with lower entorhinal cortex volume and lower cortical thickness. Differential associations emerged between colonization by specific bacteria/serum antibacterial IgG responses and MRI outcomes.
Discussion: In an elderly cohort, clinical, microbiological, and serological features of periodontitis were associated with MRI findings related to ADRD risk. Further investigation of causal associations is warranted.
(© 2024 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)
Methods: We analyzed 468 participants with clinical periodontal data, microbial plaque and serum samples, and brain MRIs. We tested the association of periodontitis features with MRI features, after adjusting for multiple risk factors for Alzheimer's disease/Alzheimer's disease-related dementia (AD/ADRD).
Results: In fully adjusted models, having more teeth was associated with lower odds for infarcts, lower white matter hyperintensity (WMH) volume, higher entorhinal cortex volume, and higher cortical thickness. Higher extent of periodontitis was associated with lower entorhinal cortex volume and lower cortical thickness. Differential associations emerged between colonization by specific bacteria/serum antibacterial IgG responses and MRI outcomes.
Discussion: In an elderly cohort, clinical, microbiological, and serological features of periodontitis were associated with MRI findings related to ADRD risk. Further investigation of causal associations is warranted.
(© 2024 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)