학술논문
Pediatric Laryngopharyngeal Reflux in the Last Decade: What Is New and Where to Next?
Document Type
Academic Journal
Author
Sofokleous V; Department of Pediatric Otorhinolaryngology, Athens Children's Hospital 'P. & A. Kyriakou', 115 27 Athens, Greece.; Papadopoulou AM; Department of Pediatric Otorhinolaryngology, Athens Children's Hospital 'P. & A. Kyriakou', 115 27 Athens, Greece.; Giotakis E; 1st Department of Otorhinolaryngology-Head & Neck Surgery, University of Athens, 'Hippocration' General Hospital, 115 27 Athens, Greece.; Delides A; 2nd Department of Otorhinolaryngology-Head & Neck Surgery, University of Athens, 'Attikon' University Hospital, 124 62 Chaidari, Greece.; Kyrodimos E; 1st Department of Otorhinolaryngology-Head & Neck Surgery, University of Athens, 'Hippocration' General Hospital, 115 27 Athens, Greece.; Maragoudakis P; 2nd Department of Otorhinolaryngology-Head & Neck Surgery, University of Athens, 'Attikon' University Hospital, 124 62 Chaidari, Greece.; Psarommatis I; Department of Pediatric Otorhinolaryngology, Athens Children's Hospital 'P. & A. Kyriakou', 115 27 Athens, Greece.
Source
Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101606588 Publication Model: Electronic Cited Medium: Print ISSN: 2077-0383 (Print) Linking ISSN: 20770383 NLM ISO Abbreviation: J Clin Med Subsets: PubMed not MEDLINE
Subject
Language
English
ISSN
2077-0383
Abstract
Background: Laryngopharyngeal reflux may affect people of any age; still, most of the accumulated knowledge concerns adults, and evidence regarding pediatric populations remains relatively restricted. This study aims to review the most recent and emerging aspects of pediatric laryngopharyngeal reflux from the last ten years. It also attempts to identify gaps in knowledge and highlight discrepancies that future research should urgently address.
Methods: An electronic search of the MEDLINE database was conducted, limited to January 2012 through December 2021. Non-English language articles, case reports, and studies that concerned a purely or predominantly adult population were excluded. The information from the articles with the most relevant contribution was initially categorized by theme and subsequently synthesized into a narrative form.
Results: 86 articles were included, of which 27 were review articles, eight were surveys, and 51 were original articles. Our review systematically maps the research done in the last decade and provides an updated overview and the current state-of-the-art in this subject.
Conclusions: Despite discrepancies and heterogeneity in accumulating research, evidence gathered so far endorses a need for refining an escalating multiparameter diagnostic approach. A step-wise therapeutic plan appears to be the most reasonable management approach, starting with behavioral changes for mild to moderate, uncomplicated cases and escalating to personalized pharmacotherapy options for severe or nonresponsive cases. Surgical options could be considered in the most severe cases when potentially life-threatening symptoms persist despite maximal medical therapy. Over the past decade, the amount of available evidence has been gradually increasing; however, its strength remains low. Several aspects remain markedly under-addressed, and further adequately powered, multicenter, controlled studies with uniformity in diagnostic procedures and criteria are urgently needed.
Methods: An electronic search of the MEDLINE database was conducted, limited to January 2012 through December 2021. Non-English language articles, case reports, and studies that concerned a purely or predominantly adult population were excluded. The information from the articles with the most relevant contribution was initially categorized by theme and subsequently synthesized into a narrative form.
Results: 86 articles were included, of which 27 were review articles, eight were surveys, and 51 were original articles. Our review systematically maps the research done in the last decade and provides an updated overview and the current state-of-the-art in this subject.
Conclusions: Despite discrepancies and heterogeneity in accumulating research, evidence gathered so far endorses a need for refining an escalating multiparameter diagnostic approach. A step-wise therapeutic plan appears to be the most reasonable management approach, starting with behavioral changes for mild to moderate, uncomplicated cases and escalating to personalized pharmacotherapy options for severe or nonresponsive cases. Surgical options could be considered in the most severe cases when potentially life-threatening symptoms persist despite maximal medical therapy. Over the past decade, the amount of available evidence has been gradually increasing; however, its strength remains low. Several aspects remain markedly under-addressed, and further adequately powered, multicenter, controlled studies with uniformity in diagnostic procedures and criteria are urgently needed.