학술논문
Hemoadsorption: Consensus report of the 30th Acute Disease Quality Initiative workgroup.
Document Type
Academic Journal
Author
Ankawi G; Department of Internal Medicine and Nephrology, Kind Abdulaziz University, Jeddah, Saudi Arabia.; Bagshaw SM; Department of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta and Alberta Health Services, Edmonton, Canada.; Bellomo R; Department of Critical Care, The University of Melbourne, Melbourne, Australia; Department of Intensive Care, Austin Hospital, Melbourne, Australia; Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Australia; Department of Intensive Care, Royal Melbourne Hospital, Melbourne, Australia.; Baldwin I; Department of Intensive Care and clinical research, Austin Hospital Health, Melbourne, 3084, Australia.; Basu R; Department of Critical Care Medicine, Luri Children's Hospital, Chicago, USA.; Bottari G; Pediatric Intensive Care Unit, Children Hospital Bambino Gesù, IRCSS, Rome, Italy.; Cantaluppi V; Nephrology and Kidney Transplantation Unit, University of Piemonte Orientale (UPO), AOU 'Maggiore della Carità', Novara 28100, Italy.; Clark W; Davidson School of Chemical Engineering, Purdue University, West Lafayette, Indiana USA.; De Rosa S; Centre for Medical Science - CISMed, University of Trento, Trento, Italy.; Forni LG; Department of Critical Care, Royal Surrey Hospital Foundation Trust, Egerton Road, Guildford GU2 7XX, Surrey, UK; School of Medicine, Faculty of Health Sciences, Kate Granger Building, University of Surrey, Guildford GU2 7YH, Surrey, UK.; Fuhrman D; Department of Critical Care Medicine and Pediatrics, Program for Critical Care Nephrology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Goldstein S; Department of Nephrology and Center for Acute Nephrology, University of Cincinnati Department of Pediatrics, Cincinnati Children's Hospital, Cincinnati, USA.; Gomez H; Department of Critical Care, University of Pittsburgh Medical Centre, Pittsburgh, USA.; Husain-Syed F; Department of Internal Medicine II, University Hospital Giessen and Marburg, Justus-Liebig-University Giessen, Giessen, Germany.; Joannidis M; Division of Intensive Care and Emergency Medicine, Department of Internal Medicine, Medical University Innsbruck, Innsbruck, Austria.; Kashani K; Division of Nephrology and Hypertension, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN, USA.; Lorenzin A; Department of Nephrology, Dialysis, and Transplantation. St. Bortolo Hospital, Vicenza, Italy International Renal Research Institute of Vicenza (IRRIV), Vicenza, Italy.; Mehta R; Department of Medicine, University of California at San Diego, San Diego, USA.; Murray PT; School of Medicine, University College Dublin, Dublin, Ireland.; Murugan R; Program for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Ostermann M; King's College London, Guy's & St Thomas' Hospital, Department of Critical Care, Westminster Bridge Road, London, UK.; Pannu N; Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.; Premuzic V; Department of Nephrology, Hypertension, Dialysis and Transplantation, UHC Zagreb; School of Medicine, University of Zagreb, Croatia.; Prowle J; William Harvey Research Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK.; Reis T; Department of Nephrology, Dialysis and Kidney Transplantation, Fenix Nephrology, São Paulo, Brazil; Department of Intensive Care Nephrology, Syrian-Lebanese Hospital, São Paulo, Brazil; Laboratory of Molecular Pharmacology, Faculty of Health Sciences, University of Brasília, Brasília, Brazil.; Rimmelé T; Anesthesiology and Critical Care Medicine, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France.; Ronco C; Department of Medcine, Padua University, Padua, Italy; Nephrology, Department of Nephrology, San Bortolo Hospital, Vicenza, Italy; International Renal Research Institute, Vicenza, Italy.; Rosner M; University of Virginia Health, Division of Nephrology, Charlottesville, VA, USA 22908.; Schneider A; Adult Intensive Care Unit, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.; See E; Department of Intensive Care, Royal Melbourne Hospital, Melbourne, Australia.; Soranno D; Indiana University School of Medicine, Departments of Pediatric, Pediatric Nephrology, Indianapolis, USA; Purdue University, Department of Bioengineering, West Lafayette, USA.; Villa G; Department of Intensive Care, University of Florence, Florence, Italy.; Whaley-Connell A; Research Service, Harry S. Truman Memorial Veterans Hospital, Columbia, MO, USA; Diabetes and Cardiovascular Center, University of Missouri-Columbia School of Medicine, Columbia, MO, USA; Division of Nephrology and Hypertension, University of Missouri-Columbia School of Medicine, Columbia, MO, USA; Division of Endocrinology and Metabolism, University of Missouri Columbia School of Medicine, Columbia, MO, USA; Department of Medicine, University of Missouri-Columbia School of Medicine, Columbia, MO, USA.; Zarbock A; Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany, and Outcomes Research Consortium, Cleveland, OH, USA.
Source
Publisher: Oxford University Press Country of Publication: England NLM ID: 8706402 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2385 (Electronic) Linking ISSN: 09310509 NLM ISO Abbreviation: Nephrol Dial Transplant Subsets: MEDLINE
Subject
Language
English
Abstract
Adsorption-based extracorporeal therapies have been subject to technical developments and clinical application for close to five decades. More recently, new technological developments in membrane and sorbent manipulation have made it possible to deliver more biocompatible extracorporeal adsorption therapies to patients with a variety of conditions. There are several key rationales based on physicochemical principles and clinical considerations that justify the application and investigation of such therapies as evidenced by multiple ex-vivo, experimental, and clinical observations. Accordingly, unspecific adsorptive extracorporeal therapies have now been applied to the treatment of a wide array of conditions from poisoning to drug overdoses, to inflammatory states and sepsis, and acute or chronic liver and kidney failure. In response to the rapidly expanding knowledge base and increased clinical evidence, we convened an Acute Disease Quality Initiative (ADQI) consensus conference dedicated to such treatment. The data show that hemoadsorption has clinically acceptable short-term biocompatibility and safety, technical feasibility, and experimental demonstration of specified target molecule removal. Pilot studies demonstrate potentially beneficial effects on physiology and larger studies of endotoxin-based hemoadsorption have identified possible target phenotypes for larger randomized controlled trials (RCTs). Moreover, in a variety of endogenous and exogenous intoxications, removal of target molecules has been confirmed in vivo. However, some studies have raised concerns about harm or failed to deliver benefits. Thus, despite many achievements, modern hemoadsorption remains a novel and experimental intervention with limited data, and a large research agenda.
(© The Author(s) 2024. Published by Oxford University Press on behalf of the ERA.)
(© The Author(s) 2024. Published by Oxford University Press on behalf of the ERA.)