학술논문
Volumetric Analysis of Spheno-Orbital Meningiomas: Prognostic Correlation and a Compartmentalized Approach.
Document Type
Academic Journal
Author
Zohdy YM; Department of Neurosurgery, School of Medicine, Emory University, Atlanta , Georgia , USA.; Jacob F; Department of Neurosurgery, School of Medicine, Emory University, Atlanta , Georgia , USA.; Agam M; Department of Neurosurgery, School of Medicine, Emory University, Atlanta , Georgia , USA.; Alawieh A; Department of Neurosurgery, School of Medicine, Emory University, Atlanta , Georgia , USA.; Bray D; Department of Neurosurgery, School of Medicine, Emory University, Atlanta , Georgia , USA.; Barbero JMR; Department of Neurosurgery, School of Medicine, Emory University, Atlanta , Georgia , USA.; Argaw SA; Rollins School of Public Health, Emory University, Atlanta , Georgia , USA.; Maldonado J; Department of Neurosurgery, School of Medicine, Emory University, Atlanta , Georgia , USA.; Rodas A; Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Emory University, Atlanta , Georgia , USA.; Sudhakar V; Department of Neurosurgery, School of Medicine, Emory University, Atlanta , Georgia , USA.; Porto E; Department of Neurosurgery, School of Medicine, Emory University, Atlanta , Georgia , USA.; Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan , Italy.; Peragallo JH; Department of Ophthalmology, Emory University School of Medicine, Atlanta , Georgia , USA.; Department of Pediatrics, Emory University School of Medicine, Atlanta , Georgia , USA.; Olson JJ; Department of Neurosurgery, School of Medicine, Emory University, Atlanta , Georgia , USA.; Pradilla G; Department of Neurosurgery, School of Medicine, Emory University, Atlanta , Georgia , USA.; Garzon-Muvdi T; Department of Neurosurgery, School of Medicine, Emory University, Atlanta , Georgia , USA.
Source
Publisher: Lippincott Williams & Wilkins, Inc Country of Publication: United States NLM ID: 7802914 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4040 (Electronic) Linking ISSN: 0148396X NLM ISO Abbreviation: Neurosurgery Subsets: MEDLINE
Subject
Language
English
Abstract
Background and Objectives: Spheno-orbital meningiomas arise from the arachnoid villi cap cells at the sphenoid ridge and have the ability to spread through soft tissue extension and cranial bone invasion. Owing to their orbital hyperostosis and intraorbital soft tissue extension, they commonly present with ophthalmologic manifestations. This study aims to investigate the correlation between tumor volume with the presenting symptoms and postoperative outcomes.
Methods: This retrospective study analyzed patients who underwent surgical resection of spheno-orbital meningiomas. Tumor volumes in different compartments were measured using preoperative and postoperative imaging. Linear and logistic regression analyses were used to identify correlations between tumor volumes and presenting symptoms preoperatively and postoperative outcomes.
Results: Sixty-six patients were included in this study, of whom 86.4% had proptosis, 80.3% had decreased visual acuity (VA), 30.3% had visual field defects, and 13.6% had periorbital edema. Preoperatively, proptosis linearly correlated with intraosseous tumor volume (coefficient = 0.6, P < .001), while the decrease in baseline VA correlated with the intraorbital tumor volume (coefficient = 0.3, P = .01). The odds of periorbital edema were found to increase with an increase in intraosseous tumor volume with an adjusted odds ratio of 1.4 (95% CI, 1.1-1.7, P = .003), while the odds of visual field defects were found to increase with an increase in intraorbital tumor volume with an adjusted odds ratio of 2.7 (95% CI, 1.3-5.6, P = .01). Postoperatively, the volume of intraosseous tumor resected linearly correlated with the improvement in proptosis (coefficient = 0.7, P < .001), while the volume of intraorbital tumor resected linearly correlated with improvement in VA (coefficient = 0.5, P < .001) and with a larger effect size in patients presenting with moderate-to-severe decrease in VA preoperatively (coefficient = 0.8).
Conclusion: Underscoring the importance of each tumor compartment relative to the patient's symptomatology serves as a valuable guide in implementing a compartmentalized resection approach tailored to the surgical objectives.
(Copyright © Congress of Neurological Surgeons 2023. All rights reserved.)
Methods: This retrospective study analyzed patients who underwent surgical resection of spheno-orbital meningiomas. Tumor volumes in different compartments were measured using preoperative and postoperative imaging. Linear and logistic regression analyses were used to identify correlations between tumor volumes and presenting symptoms preoperatively and postoperative outcomes.
Results: Sixty-six patients were included in this study, of whom 86.4% had proptosis, 80.3% had decreased visual acuity (VA), 30.3% had visual field defects, and 13.6% had periorbital edema. Preoperatively, proptosis linearly correlated with intraosseous tumor volume (coefficient = 0.6, P < .001), while the decrease in baseline VA correlated with the intraorbital tumor volume (coefficient = 0.3, P = .01). The odds of periorbital edema were found to increase with an increase in intraosseous tumor volume with an adjusted odds ratio of 1.4 (95% CI, 1.1-1.7, P = .003), while the odds of visual field defects were found to increase with an increase in intraorbital tumor volume with an adjusted odds ratio of 2.7 (95% CI, 1.3-5.6, P = .01). Postoperatively, the volume of intraosseous tumor resected linearly correlated with the improvement in proptosis (coefficient = 0.7, P < .001), while the volume of intraorbital tumor resected linearly correlated with improvement in VA (coefficient = 0.5, P < .001) and with a larger effect size in patients presenting with moderate-to-severe decrease in VA preoperatively (coefficient = 0.8).
Conclusion: Underscoring the importance of each tumor compartment relative to the patient's symptomatology serves as a valuable guide in implementing a compartmentalized resection approach tailored to the surgical objectives.
(Copyright © Congress of Neurological Surgeons 2023. All rights reserved.)