학술논문
Time-course RNAseq data of murine AB1 mesothelioma and Renca renal cancer following immune checkpoint therapy.
Document Type
Academic Journal
Author
Chin WL; National Centre for Asbestos Related Diseases, Nedlands, WA, 6009, Australia.; Medical School, University of Western Australia, Crawley, WA, 6009, Australia.; University of Western Australia, Crawley, WA, 6009, Australia.; Department of Medical Oncology, Sir Charles Gairdner Hospital, Nedlands, WA, 6009, Australia.; Institute for Respiratory Health, Nedlands, WA, 6009, Australia.; Zemek RM; National Centre for Asbestos Related Diseases, Nedlands, WA, 6009, Australia.; School of Biomedical Sciences, University of Western Australia, Crawley, WA, 6009, Australia.; Telethon Kids Institute, University of Western Australia, West Perth, WA, 6872, Australia.; Tilsed CM; National Centre for Asbestos Related Diseases, Nedlands, WA, 6009, Australia.; School of Biomedical Sciences, University of Western Australia, Crawley, WA, 6009, Australia.; Forrest ARR; Harry Perkins Institute of Medical Research, QEII Medical Centre and Centre for Medical Research, The University of Western Australia, Nedlands, Perth, WA, 6009, Australia.; Fear VS; National Centre for Asbestos Related Diseases, Nedlands, WA, 6009, Australia.; School of Biomedical Sciences, University of Western Australia, Crawley, WA, 6009, Australia.; Telethon Kids Institute, University of Western Australia, West Perth, WA, 6872, Australia.; Forbes C; National Centre for Asbestos Related Diseases, Nedlands, WA, 6009, Australia.; School of Biomedical Sciences, University of Western Australia, Crawley, WA, 6009, Australia.; Telethon Kids Institute, University of Western Australia, West Perth, WA, 6872, Australia.; Boon L; JJP Biologics, Warsaw, Poland.; Bosco A; School of Biomedical Sciences, University of Western Australia, Crawley, WA, 6009, Australia.; Asthma and Airway Disease Research Center, University of Arizona, Tuscon, Arizona, USA.; Department of Immunobiology, The University of Arizona, College of Medicine, Tuscon, Arizona, USA.; Guo BB; Harry Perkins Institute of Medical Research, QEII Medical Centre and Centre for Medical Research, The University of Western Australia, Nedlands, Perth, WA, 6009, Australia.; Millward MJ; Medical School, University of Western Australia, Crawley, WA, 6009, Australia.; University of Western Australia, Crawley, WA, 6009, Australia.; Nowak AK; National Centre for Asbestos Related Diseases, Nedlands, WA, 6009, Australia.; Medical School, University of Western Australia, Crawley, WA, 6009, Australia.; University of Western Australia, Crawley, WA, 6009, Australia.; Institute for Respiratory Health, Nedlands, WA, 6009, Australia.; Lake RA; National Centre for Asbestos Related Diseases, Nedlands, WA, 6009, Australia.; Institute for Respiratory Health, Nedlands, WA, 6009, Australia.; School of Biomedical Sciences, University of Western Australia, Crawley, WA, 6009, Australia.; Lesterhuis WJ; National Centre for Asbestos Related Diseases, Nedlands, WA, 6009, Australia. joost.lesterhuis@telethonkids.org.au.; School of Biomedical Sciences, University of Western Australia, Crawley, WA, 6009, Australia. joost.lesterhuis@telethonkids.org.au.; Telethon Kids Institute, University of Western Australia, West Perth, WA, 6872, Australia. joost.lesterhuis@telethonkids.org.au.; Lassmann T; Telethon Kids Institute, University of Western Australia, West Perth, WA, 6872, Australia. timo.lassmann@telethonkids.org.au.
Source
Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101640192 Publication Model: Electronic Cited Medium: Internet ISSN: 2052-4463 (Electronic) Linking ISSN: 20524463 NLM ISO Abbreviation: Sci Data Subsets: MEDLINE
Subject
Language
English
Abstract
Time-critical transcriptional events in the immune microenvironment are important for response to immune checkpoint blockade (ICB), yet these events are difficult to characterise and remain incompletely understood. Here, we present whole tumor RNA sequencing data in the context of treatment with ICB in murine models of AB1 mesothelioma and Renca renal cell cancer. We sequenced 144 bulk RNAseq samples from these two cancer types across 4 time points prior and after treatment with ICB. We also performed single-cell sequencing on 12 samples of AB1 and Renca tumors an hour before ICB administration. Our samples were equally distributed between responders and non-responders to treatment. Additionally, we sequenced AB1-HA mesothelioma tumors treated with two sample dissociation protocols to assess the impact of these protocols on the quality transcriptional information in our samples. These datasets provide time-course information to transcriptionally characterize the ICB response and provide detailed information at the single-cell level of the early tumor microenvironment prior to ICB therapy.
(© 2024. The Author(s).)
(© 2024. The Author(s).)