학술논문
Anti-stress Effect of β-Cryptoxanthin in Satsuma Mandarin Orange on Females.
Document Type
Academic Journal
Author
Unno K; Department of Neurophysiology, School of Pharmaceutical Sciences, University of Shizuoka.; Tea Science Center, Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka.; Noda S; Division of Drug Evaluation & Informatics, School of Pharmaceutical Sciences, University of Shizuoka.; Nii H; Division of Drug Evaluation & Informatics, School of Pharmaceutical Sciences, University of Shizuoka.; Kawasaki Y; Biostatistics Section, Chiba University Hospital.; Iguchi K; Department of Neurophysiology, School of Pharmaceutical Sciences, University of Shizuoka.; Yamada H; Division of Drug Evaluation & Informatics, School of Pharmaceutical Sciences, University of Shizuoka.
Source
Publisher: Pharmaceutical Society of Japan Country of Publication: Japan NLM ID: 9311984 Publication Model: Print Cited Medium: Internet ISSN: 1347-5215 (Electronic) Linking ISSN: 09186158 NLM ISO Abbreviation: Biol Pharm Bull Subsets: MEDLINE
Subject
Language
English
Abstract
Beta-cryptoxanthin (β-CRX, (3R)-β, β-caroten-3-ol) is an oxygenated carotenoid and a potent antioxidant that is abundant in Satsuma mandarin orange (Citrus unshiu MARC.), which is the most popular fruit in Japan. Since our preliminary data suggested that the ingestion of β-CRX had an anti-stress effect in female participants, the effect was evaluated in another set of female participants. The study design was a double-blind group comparison and participants (n = 23) were randomly assigned to β-CRX-rich orange juice or placebo (β-CRX was removed from orange juice) groups. β-CRX or placebo juice (125 mL, after breakfast) were consumed from 1 week prior to pharmacy practice and continued for 5 d into the practice period. Salivary α-amylase activity (sAA), a marker of sympathetic nervous system activity, was significantly higher in the evening than in the morning in the placebo-group during pharmacy practice, but not in the β-CRX-group. This result supports the anti-stress effect of β-CRX. The dose-dependency of β-CRX was observed in male mice that were loaded with stress. These results indicate that the ingestion of β-CRX is helpful to reduce stress.