학술논문
Utility of irritable bowel syndrome subtypes and most troublesome symptom in predicting disease impact and burden.
Document Type
Academic Journal
Author
Khasawneh M; Leeds Institute of Medical Research at St. James's, University of Leeds, Leeds, UK.; Leeds Gastroenterology Institute, St. James's University Hospital, Leeds, UK.; Shaikh FA; Leeds Gastroenterology Institute, St. James's University Hospital, Leeds, UK.; Ng CE; County Durham and Darlington NHS Foundation Trust, Durham, UK.; Black CJ; Leeds Institute of Medical Research at St. James's, University of Leeds, Leeds, UK.; Leeds Gastroenterology Institute, St. James's University Hospital, Leeds, UK.; Goodoory VC; Leeds Institute of Medical Research at St. James's, University of Leeds, Leeds, UK.; Leeds Gastroenterology Institute, St. James's University Hospital, Leeds, UK.; Ford AC; Leeds Institute of Medical Research at St. James's, University of Leeds, Leeds, UK.; Leeds Gastroenterology Institute, St. James's University Hospital, Leeds, UK.
Source
Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 9432572 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2982 (Electronic) Linking ISSN: 13501925 NLM ISO Abbreviation: Neurogastroenterol Motil Subsets: MEDLINE
Subject
Language
English
Abstract
Background: Little is known about the characteristics of individuals with irritable bowel syndrome (IBS) according to stool subtype or the most troublesome symptom reported by the individual, or whether these are useful in predicting the impact of IBS.
Methods: We collected demographic, gastrointestinal, and psychological symptoms, healthcare usage and direct healthcare costs, impact on work and activities of daily living, and quality of life data from individuals with Rome IV-defined IBS.
Key Results: We recruited 752 people with Rome IV IBS. Individuals with IBS-D reported a poorer disease-specific quality of life than those with IBS-C or IBS-M (mean (SD) IBS-QOL 45.3 (23.0) for IBS-D, vs. 52.3 (19.9) for IBS-C, vs. 49.4 (22.0) for IBS-M, p = 0.005). Mean (SD) IBS-QOL scores were also lower amongst those who reported diarrhea (44.8 (22.3)) or urgency (44.6 (22.3)) as their most troublesome symptom, compared with those reporting abdominal pain (52.2 (22.9)), constipation (49.5 (21.8)), or abdominal bloating or distension (50.4 (21.3)). However, there were no differences in mean EQ-5D scores, IBS severity, levels of anxiety, depression, somatoform symptom-reporting, or gastrointestinal symptom-specific anxiety. Direct healthcare costs of IBS were similar across all subtypes and all most troublesome symptom groups, although some differences in work productivity and social leisure activities were detected.
Conclusions and Inferences: There appears to be limited variation in the characteristics of individuals with Rome IV IBS based on both stool subtypes and most troublesome symptom reported, suggesting that gastrointestinal symptoms alone have limited ability to predict disease impact and burden.
(© 2024 The Authors. Neurogastroenterology & Motility published by John Wiley & Sons Ltd.)
Methods: We collected demographic, gastrointestinal, and psychological symptoms, healthcare usage and direct healthcare costs, impact on work and activities of daily living, and quality of life data from individuals with Rome IV-defined IBS.
Key Results: We recruited 752 people with Rome IV IBS. Individuals with IBS-D reported a poorer disease-specific quality of life than those with IBS-C or IBS-M (mean (SD) IBS-QOL 45.3 (23.0) for IBS-D, vs. 52.3 (19.9) for IBS-C, vs. 49.4 (22.0) for IBS-M, p = 0.005). Mean (SD) IBS-QOL scores were also lower amongst those who reported diarrhea (44.8 (22.3)) or urgency (44.6 (22.3)) as their most troublesome symptom, compared with those reporting abdominal pain (52.2 (22.9)), constipation (49.5 (21.8)), or abdominal bloating or distension (50.4 (21.3)). However, there were no differences in mean EQ-5D scores, IBS severity, levels of anxiety, depression, somatoform symptom-reporting, or gastrointestinal symptom-specific anxiety. Direct healthcare costs of IBS were similar across all subtypes and all most troublesome symptom groups, although some differences in work productivity and social leisure activities were detected.
Conclusions and Inferences: There appears to be limited variation in the characteristics of individuals with Rome IV IBS based on both stool subtypes and most troublesome symptom reported, suggesting that gastrointestinal symptoms alone have limited ability to predict disease impact and burden.
(© 2024 The Authors. Neurogastroenterology & Motility published by John Wiley & Sons Ltd.)