학술논문
A Hematopoietic Stem Cell Transplant Recipient with Nephrotic Syndrome and Immune Complex Deposits in Tubular Basement Membrane: A Rare Case Report.
Document Type
Academic Journal
Author
Nematollahi N; Hakemi MS; Tavakoli F; Department of Nephrology and Kidney Transplant, Dr Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. farnaztavakkoli@gmail.com.; Nili F
Source
Publisher: Iranian Society of Nephrology Country of Publication: Iran NLM ID: 101316967 Publication Model: Print Cited Medium: Internet ISSN: 1735-8604 (Electronic) Linking ISSN: 17358582 NLM ISO Abbreviation: Iran J Kidney Dis Subsets: MEDLINE
Subject
Language
English
Abstract
Following allogenic hematopoietic stem cell transplantation (HSCT), graft-versus-host disease (GVHD) may develop which may affect several organs. Although the presence of nephrotic syndrome after HSCT is rare, sometimes it occurs in the setting of GVHD. The most common histological finding on kidney biopsy of patients with proteinuria owing to GVHD is membranous glomerulonephritis (MGN). However, reports of immune complex deposition in the tubular basement membrane (TBM) and glomerular basement membrane (GBM) are extremely rare. Herein we present a 65-year-old female with a history of HSCT at six years ago who was referred to Dr.Shariati Hospital in Tehran with nephrotic syndrome. Secondary serologic laboratory tests were all normal. The histopathologic study indicated diffuse GBM and TBM thickening, spike formation, infiltration of inflammatory mononuclear cells in tubulointerstitial area and acute tubular injury in light microscopy. Immunofluorescence staining showed immune complex deposits in GBM, mesangial cells, and TBM. DOI: 10.52547/ijkd.7550.