학술논문
EXPLORing Arthritis with Total-body Positron Emission Tomography.
Document Type
Academic Journal
Author
Chaudhari AJ; Department of Radiology, University of California, Davis, Davis, California.; Abdelhafez YG; Department of Radiology, University of California, Davis, Davis, California.; Nuclear Medicine Unit, South Egypt Cancer Institute, Assiut University, Assiut, Egypt.; Nardo L; Department of Radiology, University of California, Davis, Davis, California.; Raychaudhuri SP; Department of Internal Medicine - Rheumatology, University of California, Davis, Davis, California.; Northern California Veterans Affairs Medical Center, Mather, California.
Source
Publisher: Thieme Country of Publication: United States NLM ID: 9717520 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-898X (Electronic) Linking ISSN: 10897860 NLM ISO Abbreviation: Semin Musculoskelet Radiol Subsets: MEDLINE
Subject
Language
English
Abstract
Arthritis has significant adverse consequences on musculoskeletal tissues and often other organs of the body. Current methods for clinical evaluation of arthritis are suboptimal, and biomarkers that are objective and measurable indicators for monitoring of arthritis disease activity are in critical demand. Recently, total-body positron emission tomography (PET) has been developed that can collect imaging signals synchronously from the entire body at ultra-low doses and reduced scan times. These scanners have increased signal collection efficiency that overcomes several limitations of standard PET scanners in the evaluation of arthritis, and they may potentially provide biomarkers to assess local and systemic impact of the arthritis disease process. This article reviews current results from using total-body PET in the assessment of common arthritic conditions, and it outlines future opportunities and challenges.
Competing Interests: University of California, Davis, has a research agreement and a sales-based revenue-sharing agreement with United Imaging Healthcare, the manufacturer of the uEXPLORER scanner used for the studies described in this article. The work is supported in part by the National Institutes of Health (R01 AR076088, R61 AT012187, and R01 CA206187) and the National Psoriasis Foundation.
(Thieme. All rights reserved.)
Competing Interests: University of California, Davis, has a research agreement and a sales-based revenue-sharing agreement with United Imaging Healthcare, the manufacturer of the uEXPLORER scanner used for the studies described in this article. The work is supported in part by the National Institutes of Health (R01 AR076088, R61 AT012187, and R01 CA206187) and the National Psoriasis Foundation.
(Thieme. All rights reserved.)