학술논문
Bromodomain AAA+ ATPases get into shape.
Document Type
Academic Journal
Author
Murawska M; Biomedical Center, Physiological Chemistry, Ludwig-Maximilians-University of Munich, Planegg-Martinsried, Germany.; Ladurner AG; Biomedical Center, Physiological Chemistry, Ludwig-Maximilians-University of Munich, Planegg-Martinsried, Germany.
Source
Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101518322 Publication Model: Print Cited Medium: Internet ISSN: 1949-1042 (Electronic) Linking ISSN: 19491034 NLM ISO Abbreviation: Nucleus Subsets: MEDLINE
Subject
Language
English
Abstract
Bromodomain AAA+ ATPases ( A TPases a ssociated with diverse cellular a ctivities) are emerging as oncogenic proteins and compelling targets for anticancer therapies. However, structural and biochemical insight into these machines is missing. A recent study by Cho et al . reports the first cryo-EM structure of a bromodomain AAA+ ATPase and provides first insights into the functions of this putative histone chaperone.