학술논문
The Vascularised Chamber as an In Vivo Bioreactor.
Document Type
Academic Journal
Author
Yap KK; O'Brien Institute, Department of St Vincent's Institute, Victoria, Australia; University of Melbourne Department of Surgery, St Vincent's Hospital Melbourne, Victoria, Australia; Department of Plastic and Reconstructive Surgery, St Vincent's Hospital Melbourne, Victoria, Australia. Electronic address: kyap@svi.edu.au.; Yeoh GC; Harry Perkins Institute of Medical Research and Centre for Medical Research, University of Western Australia, Western Australia, Australia.; Morrison WA; O'Brien Institute, Department of St Vincent's Institute, Victoria, Australia; University of Melbourne Department of Surgery, St Vincent's Hospital Melbourne, Victoria, Australia; Department of Plastic and Reconstructive Surgery, St Vincent's Hospital Melbourne, Victoria, Australia; Australian Catholic University, Victoria, Australia.; Mitchell GM; O'Brien Institute, Department of St Vincent's Institute, Victoria, Australia; University of Melbourne Department of Surgery, St Vincent's Hospital Melbourne, Victoria, Australia; Australian Catholic University, Victoria, Australia.
Source
Publisher: Elsevier Science Publishers Country of Publication: England NLM ID: 8310903 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3096 (Electronic) Linking ISSN: 01677799 NLM ISO Abbreviation: Trends Biotechnol
Subject
Language
English
Abstract
Vascularisation is key to developing large transplantable tissue constructs capable of providing therapeutic benefits. The vascularised tissue engineering chamber originates from surgical concepts in tissue prefabrication and microsurgery. It serves as an in vivo bioreactor in the form of a closed, protected space surgically created and embedded within the body by fitting a noncollapsible chamber around major blood vessels. This creates a highly angiogenic environment which facilitates the engraftment and survival of transplanted cells and tissue constructs. This article outlines the chamber concept and explores its application in the context of recent advances in biomedical engineering, and how this can play a role in the future of cell therapies and regenerative medicine.
(Copyright © 2018 Elsevier Ltd. All rights reserved.)
(Copyright © 2018 Elsevier Ltd. All rights reserved.)