학술논문
Association of maternal, obstetric, fetal, and neonatal mortality outcomes with Lady Health Worker coverage from a cross-sectional survey of >10,000 households in Gilgit-Baltistan, Pakistan.
Document Type
Academic Journal
Author
Farrar DS; Centre for Global Child Health, The Hospital for Sick Children, Toronto, Ontario, Canada.; Pell LG; Centre for Global Child Health, The Hospital for Sick Children, Toronto, Ontario, Canada.; Muhammad Y; Gilgit Regional Office, Aga Khan Health Service-Pakistan, Gilgit-Baltistan, Pakistan.; Khan SH; Gilgit Regional Office, Aga Khan Health Service-Pakistan, Gilgit-Baltistan, Pakistan.; Tanner Z; Centre for Global Child Health, The Hospital for Sick Children, Toronto, Ontario, Canada.; Bassani DG; Centre for Global Child Health, The Hospital for Sick Children, Toronto, Ontario, Canada.; Temerty Faculty of Medicine, Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada.; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.; Ahmed I; Centre of Excellence in Women and Child Health, Aga Khan University, Karachi, Sindh, Pakistan.; Karim M; Centre of Excellence in Women and Child Health, Aga Khan University, Karachi, Sindh, Pakistan.; Madhani F; Aga Khan Health Service-Pakistan, Karachi, Sindh, Pakistan.; Brain and Mind Institute, Aga Khan University, Karachi, Sindh, Pakistan.; Paracha S; Aga Khan Health Service-Pakistan, Karachi, Sindh, Pakistan.; Khan MA; Gilgit Regional Office, Aga Khan Health Service-Pakistan, Gilgit-Baltistan, Pakistan.; Soofi SB; Centre of Excellence in Women and Child Health, Aga Khan University, Karachi, Sindh, Pakistan.; Taljaard M; Ottawa Hospital Research Institute, Clinical Epidemiology Program, Ottawa, Ontario, Canada.; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada.; Spitzer RF; Department of Obstetrics and Gynaecology, University of Toronto, Toronto, Ontario, Canada.; Section of Gynecology, The Hospital for Sick Children, Toronto, Ontario, Canada.; Abu Fadaleh SM; Centre for Global Child Health, The Hospital for Sick Children, Toronto, Ontario, Canada.; Bhutta ZA; Centre for Global Child Health, The Hospital for Sick Children, Toronto, Ontario, Canada.; Temerty Faculty of Medicine, Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada.; Centre of Excellence in Women and Child Health, Aga Khan University, Karachi, Sindh, Pakistan.; Institute for Global Health & Development, The Aga Khan University, South-Central Asia & East Africa, Karachi, Pakistan.; Morris SK; Centre for Global Child Health, The Hospital for Sick Children, Toronto, Ontario, Canada.; Temerty Faculty of Medicine, Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada.; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.; Division of Infectious Diseases, The Hospital for Sick Children, Toronto, Canada.
Source
Publisher: Public Library of Science Country of Publication: United States NLM ID: 9918283779606676 Publication Model: eCollection Cited Medium: Internet ISSN: 2767-3375 (Electronic) Linking ISSN: 27673375 NLM ISO Abbreviation: PLOS Glob Public Health Subsets: PubMed not MEDLINE
Subject
Language
English
Abstract
Pakistan has among the highest rates of maternal, perinatal, and neonatal mortality globally. Many of these deaths are potentially preventable with low-cost, scalable interventions delivered through community-based health worker programs to the most remote communities. We conducted a cross-sectional survey of 10,264 households during the baseline phase of a cluster randomized controlled trial (cRCT) in Gilgit-Baltistan, Pakistan from June-August 2021. The survey was conducted through a stratified, two-stage sampling design with the objective of estimating the neonatal mortality rate (NMR) within the study catchment area, and informing implementation of the cRCT. Study outcomes were self-reported and included neonatal death, stillbirth, health facility delivery, maternal death, postpartum hemorrhage (PPH), and Lady Health Worker (LHW) coverage. Summary statistics (proportions and rates) were weighted according to the sampling design, and mixed-effects Poisson regression was conducted to explore the relationship between LHW coverage and maternal/newborn outcomes. We identified 7,600 women who gave birth in the past five years, among whom 13% reported experiencing PPH. The maternal mortality ratio was 225 maternal deaths per 100,000 live births (95% confidence interval [CI] 137-369). Among 12,376 total births, the stillbirth rate was 41.4 per 1,000 births (95% CI 36.8-46.7) and the perinatal mortality rate was 53.0 per 1,000 births (95% CI 47.6-59.0). Among 11,863 live births, NMR was 16.2 per 1,000 live births (95% CI 13.6-19.3) and 65% were delivered at a health facility. LHW home visits were associated with declines in PPH (risk ratio [RR] 0.89 per each additional visit, 95% CI 0.83-0.96) and late neonatal mortality (RR 0.80, 95% CI 0.67-0.97). Intracluster correlation coefficients were also estimated to inform the planning of future trials. The high rates of maternal, perinatal, and neonatal death in Gilgit-Baltistan continue to fall behind targets of the 2030 Sustainable Development Goals.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2024 Farrar et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2024 Farrar et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)