학술논문
Relationship Between 18 F-fluorodeoxyglucose Uptake on Positron Emission Tomography and Aortic Calcification.
Document Type
Academic Journal
Author
Okamura Y; Department of Cardiovascular Medicine, Toho University Graduate School of Medicine, Tokyo, Japan.; Nakanishi R; Department of Cardiovascular Medicine, Toho University Graduate School of Medicine, Tokyo, Japan.; Hashimoto H; Division of Cardiovascular Medicine, Department of Internal Medicine, Toho University Faculty of Medicine, Tokyo, Japan.; Mizumura S; Department of Radiology, Toho University Faculty of Medicine, Tokyo, Japan.; Homma S; Department of Respiratory Medicine, School of Medicine, Faculty of Medicine, Toho University, Tokyo, Japan.; Ikeda T; Department of Cardiovascular Medicine, Toho University Graduate School of Medicine, Tokyo, Japan.
Source
Publisher: Japanese Society of Nuclear Cardiology Country of Publication: Japan NLM ID: 101747118 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2424-1741 (Electronic) Linking ISSN: 21893926 NLM ISO Abbreviation: Ann Nucl Cardiol Subsets: PubMed not MEDLINE
Subject
Language
English
Abstract
Introduction : Although 18 F-fluorodeoxyglucose (FDG) positron emission tomography (PET) has been widely utilized to assess the extent of inflammation, the association between the extent and severity of atherosclerosis and 18 F-FDG uptake on PET remains unexamined. The current study aimed to investigate whether aortic calcium (AC) scores were associated with increased aortic uptake of 18 F-FDG on PET. Methods : A total of 167 consecutive patients with suspected lung cancer but unproven malignancy who underwent non-contrast-enhanced computed tomography (CT) and 18 F-FDG PET/CT were enrolled. The average standardized uptake values in the ascending aorta were used to calculate the target-to-background ratio (Mean TBR). The total (thoracic and abdominal) AC scores were measured on non-contrast-enhanced chest and abdominal CT using the Agatston method, and were categorized into three groups (0, 1-399, and ≥400). The relationship between total AC scores and 18 F-FDG uptake in the ascending aorta was assessed using multivariate linear regression analysis. Results : In total, 68.26% were male, and a mean age was 67.10±14.70 years. Mean TBR values increased progressively with total AC score 0, 1-399, and ≥400 (1.01±0.07, 1.08±0.09, and 1.11±0.11, respectively; p<0.00001). Multivariate linear regression analysis revealed that increased total AC scores of 1-399 ( β =0.06, 95% CI: 0.01-0.11, p=0.02) and ≥400 ( β =0.11, 95% CI: 0.06-0.16, p<0.001) were significantly associated with higher Mean TBR. Conclusions : The current study demonstrated that total AC scores were associated with Mean TBR. Patients with a greater extent and severity of aortic calcifications may possess increased atherosclerotic inflammatory activity as measured by 18 F-FDG PET/CT.
Competing Interests: None.
(2022, Japanese Society of Nuclear Cardiology.)
Competing Interests: None.
(2022, Japanese Society of Nuclear Cardiology.)