학술논문

Researching COVID to Enhance Recovery (RECOVER) adult study protocol: Rationale, objectives, and design.
Document Type
Academic Journal
Author
Horwitz LI; Department of Population Health, NYU Grossman School of Medicine, New York, New York, United States of America.; Thaweethai T; Department of Biostatistics, Massachusetts General Hospital, Boston, Massachusetts, United States of America.; Brosnahan SB; Division of Pulmonary Critical Care and Sleep Medicine, NYU Langone Health, New York, New York, United States of America.; Cicek MS; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America.; Fitzgerald ML; Patient Led Research Collaboration on COVID-19, Washington, DC, United States of America.; Goldman JD; Division of Infectious Diseases, Providence Swedish Medical Center, Seattle, Washington, United States of America.; Hess R; Department of Population Health Sciences and Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.; Hodder SL; Department of Medicine, West Virginia University, Morgantown, West Virginia, United States of America.; Jacoby VL; Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, San Francisco, California, United States of America.; Jordan MR; Division of Geographic Medicine and Infectious Diseases, Tufts Medical Center, Medford, Massachusetts, United States of America.; Krishnan JA; Department of Medicine, University of Illinois Chicago, Chicago, Illinois, United States of America.; Laiyemo AO; Department of Medicine, Howard University, Washington, DC, United States of America.; Metz TD; Department of Obstetrics and Gynecology, University of Utah Health, Salt Lake City, Utah, United States of America.; Nichols L; Body Politic COVID-19 Support Group, Boston, Massachusetts, United States of America.; Patzer RE; Department of Medicine and Surgery, Health Services Research Center, Emory University School of Medicine, Atlanta, Georgia, United States of America.; Sekar A; Patient Led Research Collaboration on COVID-19, Washington, DC, United States of America.; Singer NG; Department of Medicine and Rheumatology, The MetroHealth Medical Center, Cleveland, Ohio, United States of America.; Stiles LE; Department of Neurology, Stony Brook University Renaissance School of Medicine, Stony Brook, New York, United States of America.; Taylor BS; Department of Medicine, Division of Infectious Diseases and Infectious Diseases, Long School of Medicine, University of Texas Health Science Center San Antonio, San Antonio, Texas, United States of America.; Ahmed S; Department of Biostatistics, Massachusetts General Hospital, Boston, Massachusetts, United States of America.; Algren HA; Swedish Center for Research and Innovation, Providence Swedish Medical Center, Seattle, Washington, United States of America.; Anglin K; Department of Epidemiology and Biostatistics, University of California at San Francisco Institute of Global Health Sciences, San Francisco, San Francisco, California, United States of America.; Aponte-Soto L; College of Science and Health, Department of Health Sciences, DePaul University, Chicago, Illinois, United States of America.; Ashktorab H; Department of Medicine, Howard University, Washington, DC, United States of America.; Bassett IV; Medical Practice Evaluation Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.; Bedi B; Department of Medicine, Emory University, Atlanta, Georgia, United States of America.; Bhadelia N; Center for Emerging Infectious Diseases Policy and Research, Boston University School of Medicine, Boston, Massachusetts, United States of America.; Bime C; Department of Medicine, University of Arizona, Tucson, Arizona, United States of America.; Bind MC; Department of Biostatistics, Massachusetts General Hospital, Boston, Massachusetts, United States of America.; Black LJ; Department of Clinical Research, Sanford Research, Sioux Falls, South Dakota, United States of America.; Blomkalns AL; Department of Emergency Medicine, Stanford University, Stanford, California, United States of America.; Brim H; Department of Pathology, Howard University, Washington, DC, United States of America.; Castro M; Division of Pulmonary and Critical Care, University of Kansas Medical Center, Kansas City, Kansas City, United States of America.; Chan J; Department of Biostatistics, Massachusetts General Hospital, Boston, Massachusetts, United States of America.; Charney AW; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; Chen BK; Division of Infectious Disease, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; Chen LQ; Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America.; Chen P; Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, United States of America.; Chestek D; Department of Emergency Medicine, University of Illinois Chicago, Chicago, Illinois, United States of America.; Chibnik LB; Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, United States of America.; Chow DC; Department of Medicine, University of Hawaii at Manoa John A. Burns School of Medicine, Honolulu, Hawaii, United States of America.; Chu HY; Department of Allergy & Infectious Diseases, University of Washington, Seattle, Washington, United States of America.; Clifton RG; Department of Biostatistics, George Washington University, Washington, DC, United States of America.; Collins S; Department of Medicine, Emory University, Atlanta, Georgia, United States of America.; Costantine MM; Department of Obstetrics and Gynecology, The Ohio State University Hospital, Columbus, Ohio, United States of America.; Cribbs SK; Department of Medicine, Emory University, Atlanta, Georgia, United States of America.; Deeks SG; Department of Medicine, University of California, San Francisco, San Francisco, California, United States of America.; Dickinson JD; Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, United States of America.; Donohue SE; Department of Research Services, University of Illinois College of Medicine, Peoria, Illinois, United States of America.; Durstenfeld MS; Department of Medicine, Division of Cardiology at Zuckerberg San Francisco General, University of California San Francisco, San Francisco, California, United States of America.; Emery IF; MaineHealth Institute for Research, MaineHealth, Scarborough, Maine, United States of America.; Erlandson KM; Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America.; Facelli JC; Department of Biomedical Informatics and Clinical and Translational Science Institute, University of Utah, Salt Lake City, Utah, United States of America.; Farah-Abraham R; Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, United States of America.; Finn AV; Department of Pathology, CVPath Institute, Gaithersburg, Maryland, United States of America.; Fischer MS; Department of Medicine, Division of Infectious Diseases and Infectious Diseases, Long School of Medicine, University of Texas Health Science Center San Antonio, San Antonio, Texas, United States of America.; Flaherman VJ; Department of Pediatrics, University of California, San Francisco, San Francisco, California, United States of America.; Fleurimont J; Mile Square Health Center, University of Illinois Chicago, University of Illinois Chicago, Chicago, Illinois, United States of America.; Fonseca V; Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana, United States of America.; Gallagher EJ; Department of Endocrinology, Diabetes and Bone Disease, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; Gander JC; Center for Research and Evaluation, Kaiser Permanente of Georgia, Atlanta, Georgia, United States of America.; Gennaro ML; Public Health Research Institute and Department of Medicine, Rutgers New Jersey Medical School, Newark, New Jersey, United States of America.; Gibson KS; Department of Obstetrics and Gynecology, MetroHealth System, Cleveland, Ohio, United States of America.; Go M; Department of Medicine, Stanford University, Stanford, California, United States of America.; Goodman SN; Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, California, United States of America.; Granger JP; Department of Physiology & Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, United States of America.; Greenway FL; Clinical Trials, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America.; Hafner JW; Department of Emergency Medicine, OSF Saint Francis Medical Center, Peoria, Illinois, United States of America.; Han JE; Department of Pulmonary and Critical Care, Emory University School of Medicine, Atlanta, Georgia, United States of America.; Harkins MS; Department of Internal Medicine University of New Mexico, Health Science Center, Albuquerque, New Mexico, United States of America.; Hauser KSP; Clinical Research Center, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America.; Heath JR; Department of Bioengineering, Institute for Systems Biology, Seattle, Washington, United States of America.; Hernandez CR; Clinical Research Center, University Hospitals Cleveland Medical Center, Cleveland, Ohio, United States of America.; Ho O; Seattle Children's Therapeutics, Seattle, Washington, United States of America.; Hoffman MK; Department of Obstetrics and Gynecology, Christiana Care Health Services, Newark, Delaware, United States of America.; Hoover SE; Department of Clinical Research, Sanford Research, Sioux Falls, South Dakota, United States of America.; Horowitz CR; Institute for Health Equity Research, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; Hsu H; Department of Internal Medicine, University of Arizona, Phoenix, Arizona, United States of America.; Hsue PY; Department of Medicine, University of California, San Francisco, San Francisco, California, United States of America.; Hughes BL; Department of Obstetrics and Gynecology, Duke University, Durham, North Carolina, United States of America.; Jagannathan P; Department of Medicine, Stanford University, Stanford, California, United States of America.; James JA; Department of Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America.; John J; Department of Family Medicine, Cambridge Health Alliance, Cambridge, Massachusetts, United States of America.; Jolley S; Department of Pulmonary and Critical Care Medicine, University of Colorado, Aurora, Colorado, United States of America.; Judd SE; Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America.; Juskowich JJ; Department of Medicine, Division of Infectious Diseases, West Virginia School of Medicine, Morgantown, West Virginia, United States of America.; Kanjilal DG; Department of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America.; Karlson EW; Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America.; Katz SD; Department of Medicine, NYU Langone Health, New York, New York, United States of America.; Kelly JD; Department of Medicine, University of California, San Francisco, San Francisco, California, United States of America.; Kelly SW; Department of Pediatrics & Department of Research Services, University of Illinois College of Medicine, Peoria, Illinois, United States of America.; Kim AY; Department of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America.; Kirwan JP; Department Integrated Physiology and Molecular Medicine, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America.; Knox KS; Department of Internal Medicine, University of Arizona, Phoenix, Arizona, United States of America.; Kumar A; Department of Medicine, Stanford University, Stanford, California, United States of America.; Lamendola-Essel MF; Department of Medicine, NYU Langone Health, New York, New York, United States of America.; Lanca M; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, United States of America.; Lee-Lannotti JK; Department of Internal Medicine and Neurology, University of Arizona College of Medicine Phoenix, Phoenix, Arizona, United States of America.; Lefebvre RC; Communications Practice Area, RTI International, Research Triangle Park, North Carolina, United States of America.; Levy BD; Department of Internal Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America.; Lin JY; Department of Emergency Medicine, University of Illinois Chicago, Chicago, Illinois, United States of America.; Logarbo BP Jr; Tulane Center for Clinical Research, Tulane University School of Medicine, New Orleans, Louisiana, United States of America.; Logue JK; Department of Medicine, University of Washington, Seattle, Washington, United States of America.; Longo MT; Tulane Center for Clinical Neurosciences, Tulane School of Medicine, New Orleans, Louisiana, United States of America.; Luciano CA; Department of Neurology, University of Puerto Rico School of Medicine, San Juan, Puerto Rico, United States of America.; Lutrick K; Department of Family & Community Medicine, University of Arizona, College of Medicine - Tucson, Tucson, Arizona, United States of America.; Malakooti SK; Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America.; Mallett G; Department of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois, United States of America.; Maranga G; Department of Population Health, NYU Grossman School of Medicine, New York, New York, United States of America.; Marathe JG; Department of Medicine, Section of Infectious Diseases, Boston University Medical Center, Boston, Massachusetts, United States of America.; Marconi VC; Department of Medicine, Infectious Diseases and Department of Global Health, Emory University School of Medicine, Atlanta, Georgia, United States of America.; Marshall GD; Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, United States of America.; Martin CF; Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, United States of America.; Martin JN; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, United States of America.; May HT; Department of Cardiology, Intermountain Medical Center, Salt Lake City, Utah, United States of America.; McComsey GA; Department of Medicine, Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America.; McDonald D; Department of Allergy & Infectious Diseases, University of Washington, Seattle, Washington, United States of America.; Mendez-Figueroa H; Department of Obstetrics, Gynecology and Reproductive Sciences, University of Texas Health Science Center at Houston, Houston, Texas, United States of America.; Miele L; Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, Louisiana, United States of America.; Mittleman MA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.; Mohandas S; Department of Infectious Diseases, Children's Hospital Los Angeles, University of Southern California, Los Angeles, California, United States of America.; Mouchati C; Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America.; Mullington JM; Department of Neurology and Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America.; Nadkarni GN; Division of General Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; Nahin ER; Department of Medicine, NYU Langone Health, New York, New York, United States of America.; Neuman RB; Division of Cardiology, Kaiser Permanente of Georgia, Atlanta, Georgia, United States of America.; Newman LT; Department of Social, Statistical and Environmental Sciences, RTI International, Research Triangle Park, North Carolina, United States of America.; Nguyen A; Department of Biostatistics, Massachusetts General Hospital, Boston, Massachusetts, United States of America.; Nikolich JZ; Department of Immunobiology, University of Arizona College of Medicine, Tucson, Arizona, United States of America.; Ofotokun I; Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, United States of America.; Ogbogu PU; Division of Pediatric Allergy, Immunology, and Rheumatology, University Hospitals Rainbow Babies and Children's Hospital, Cleveland, Ohio, United States of America.; Palatnik A; Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America.; Palomares KTS; Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Saint Peter's University Hospital, New Brunswick, New Jersey, United States of America.; Parimon T; Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, United States of America.; Parry S; Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.; Parthasarathy S; Department of Medicine, University of Arizona, Tucson, Arizona, United States of America.; Patterson TF; Department of Medicine, Department of Infectious Disease, University of Texas Health, San Antonio, Texas, United States of America.; Pearman A; Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America.; Peluso MJ; Division of HIV, Infectious Disease, and Global Medicine, University of California, San Francisco, California, United States of America.; Pemu P; Department of Medicine, Morehouse School of Medicine, Atlanta, Georgia, United States of America.; Pettker CM; Department of Obstetrics, Gynecology & Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut, United States of America.; Plunkett BA; Department of Obstetrics and Gynecology, NorthShore University Health System, Evanston, Illinois, United States of America.; Pogreba-Brown K; Department of Epidemiology and Biostatistics, University of Arizona, Tucson, Arizona, United States of America.; Poppas A; Division of Cardiology, Warren Alpert Medical School of Brown University, Providence, Rhode Island, United States of America.; Porterfield JZ; Department of Internal Medicine, Division of Infectious Diseases, University of Kentucky, Lexington, Kentucky, United States of America.; Quigley JG; Department of Medicine, Division of Hematology/Oncology, University of Illinois Chicago, Chicago, Illinois, United States of America.; Quinn DK; Department of Psychiatry and Behavioral Sciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, United States of America.; Raissy H; Department of Pediatrics, University of New Mexico, Health Sciences Center, Albuquerque, New Mexico, United States of America.; Rebello CJ; Department of Nutrition and Chronic Disease, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America.; Reddy UM; Department of Obstetrics and Gynecology, Columbia University, New York, New York, United States of America.; Reece R; Department of Medicine, Division of Infectious Diseases, West Virginia School of Medicine, Morgantown, West Virginia, United States of America.; Reeder HT; Department of Biostatistics, Massachusetts General Hospital, Boston, Massachusetts, United States of America.; Rischard FP; Department of Pulmonary and Critical Care, University of Arizona, Tucson, Arizona, United States of America.; Rosas JM; Department of Medicine, NYU Langone Health, New York, New York, United States of America.; Rosen CJ; MaineHealth Institute for Research, MaineHealth, Scarborough, Maine, United States of America.; Rouphael NG; Department of Medicine, Emory University, Atlanta, Georgia, United States of America.; Rouse DJ; Department of Obstetrics and Gynecology, Brown University, Providence, Rhode Island, United States of America.; Ruff AM; Division of Pulmonary and Critical Care, University of Kansas Medical Center, Kansas City, Kansas City, United States of America.; Saint Jean C; Department of Population Health, NYU Grossman School of Medicine, New York, New York, United States of America.; Sandoval GJ; Department of Biostatistics, George Washington University, Washington, DC, United States of America.; Santana JL; Department of Medicine, University of Puerto Rico, San Juan, Puerto Rico, United States of America.; Schlater SM; Department of Internal Medicine, University of Utah, Salt Lake City, Utah, United States of America.; Sciurba FC; Department of Medicine, Division of Pulmonary Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.; Selvaggi C; Department of Biostatistics, Massachusetts General Hospital, Boston, Massachusetts, United States of America.; Seshadri S; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center San Antonio, San Antonio, Texas, United States of America.; Sesso HD; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America.; Shah DP; Department of Population Health Sciences, Mays Cancer Center, University of Texas Health, San Antonio, Texas, United States of America.; Shemesh E; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; Sherif ZA; Department of Biochemistry & Molecular Biology, Howard University College of Medicine, Washington, DC, United States of America.; Shinnick DJ; Department of Biostatistics, Massachusetts General Hospital, Boston, Massachusetts, United States of America.; Simhan HN; Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America.; Singh U; Department of Internal Medicine, Stanford University, Stanford, California, United States of America.; Sowles A; Department of Obstetrics and Gynecology, University of Utah Health, Salt Lake City, Utah, United States of America.; Subbian V; Department of Biomedical Engineering, Department of Systems and Industrial Engineering, University of Arizona College of Engineering, Tucson, Arizona, United States of America.; Sun J; Department of Medicine, University of Illinois Chicago, Chicago, Illinois, United States of America.; Suthar MS; Department of Pediatrics, Emory Vaccine Center, Emory University, Atlanta, Georgia, United States of America.; Teunis LJ; Health Services Research Center, Emory University, Atlanta, Georgia, United States of America.; Thorp JM Jr; Department of Obstetrics and Gynecology, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, United States of America.; Ticotsky A; Department of Family Medicine, Cambridge Health Alliance, Cambridge, Massachusetts, United States of America.; Tita ATN; Department of Obstetrics and Gynecology and Center for Women's Reproductive Health, University of Alabama at Birmingham, Birmingham, Alabama, United States of America.; Tragus R; Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, United States of America.; Tuttle KR; Department of Medicine, Division of Nephrology, University of Washington School of Medicine, Spokane, Washington, United States of America.; Urdaneta AE; Department of Emergency Medicine, Stanford University, Stanford, California, United States of America.; Utz PJ; Department of Internal Medicine, Stanford University, Stanford, California, United States of America.; VanWagoner TM; Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America.; Vasey A; Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, United States of America.; Vernon SD; Department of Research, Bateman Horne Center, Salt Lake City, Utah, United States of America.; Vidal C; Department of Population Health, NYU Grossman School of Medicine, New York, New York, United States of America.; Walker T; Department of Medicine, Emory University, Atlanta, Georgia, United States of America.; Ward HD; Department of Medicine, Tufts Medical Center, Boston, Massachusetts, United States of America.; Warren DE; Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, Nebraska, United States of America.; Weeks RM; Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, Kentucky, United States of America.; Weiner SJ; Department of Biostatistics, George Washington University, Washington, DC, United States of America.; Weyer JC; Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota, United States of America.; Wheeler JL; Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota, United States of America.; Whiteheart SW; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky, United States of America.; Wiley Z; Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, United States of America.; Williams NJ; Institute for Excellence in Health Equity, NYU Grossman School of Medicine, New York, New York, United States of America.; Wisnivesky JP; Division of General Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; Wood JC; Department of Pediatrics and Radiology, Children's Hospital of Los Angeles, Los Angeles, California, United States of America.; Yee LM; Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.; Young NM; Swedish Center for Research and Innovation, Providence Swedish Medical Center, Seattle, Washington, United States of America.; Zisis SN; Department of Medicine, Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America.; Foulkes AS; Department of Biostatistics, Massachusetts General Hospital, Boston, Massachusetts, United States of America.
Source
Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
Subject
Language
English
Abstract
Importance: SARS-CoV-2 infection can result in ongoing, relapsing, or new symptoms or other health effects after the acute phase of infection; termed post-acute sequelae of SARS-CoV-2 infection (PASC), or long COVID. The characteristics, prevalence, trajectory and mechanisms of PASC are ill-defined. The objectives of the Researching COVID to Enhance Recovery (RECOVER) Multi-site Observational Study of PASC in Adults (RECOVER-Adult) are to: (1) characterize PASC prevalence; (2) characterize the symptoms, organ dysfunction, natural history, and distinct phenotypes of PASC; (3) identify demographic, social and clinical risk factors for PASC onset and recovery; and (4) define the biological mechanisms underlying PASC pathogenesis.
Methods: RECOVER-Adult is a combined prospective/retrospective cohort currently planned to enroll 14,880 adults aged ≥18 years. Eligible participants either must meet WHO criteria for suspected, probable, or confirmed infection; or must have evidence of no prior infection. Recruitment occurs at 86 sites in 33 U.S. states, Washington, DC and Puerto Rico, via facility- and community-based outreach. Participants complete quarterly questionnaires about symptoms, social determinants, vaccination status, and interim SARS-CoV-2 infections. In addition, participants contribute biospecimens and undergo physical and laboratory examinations at approximately 0, 90 and 180 days from infection or negative test date, and yearly thereafter. Some participants undergo additional testing based on specific criteria or random sampling. Patient representatives provide input on all study processes. The primary study outcome is onset of PASC, measured by signs and symptoms. A paradigm for identifying PASC cases will be defined and updated using supervised and unsupervised learning approaches with cross-validation. Logistic regression and proportional hazards regression will be conducted to investigate associations between risk factors, onset, and resolution of PASC symptoms.
Discussion: RECOVER-Adult is the first national, prospective, longitudinal cohort of PASC among US adults. Results of this study are intended to inform public health, spur clinical trials, and expand treatment options.
Registration: NCT05172024.
Competing Interests: I have read the journal’s policy and the authors of this manuscript have the following competing interests: Helen Chu reported consulting for Merck, GSK, Pfizer, Ellume, Janssen, Vindico CME, and the Bill and Melinda Gates Foundation, and receiving research support from Gates Ventures, Ellume, and Sanofi Pasteur. She also serves as a co-investigator on studies funded by Pfizer, Novavax, and GSK. Maged Costantine reported receiving grant support for work not related to RECOVER work/publications from Baxter International and Siemens Healthcare and personal consulting fees not related to this paper from Progenity, Quidel Ortho, and Siemens Healthcare. Kristine Erlandson reported research funding from Gilead Sciences and consulting payments from Gilead Sciences, Merck, and ViiV Pharmaceuticals, all paid to the University of Colorado. Emily Gallagher reported consulting for Novartis, Flare Therapeutics and Seagen. Edward Gardner reported research support (clinical trials) from Gilead Sciences, ViiV Healthcare, and Cepheid. Jason Goldman reported research support from Gilead, Eli Lilly and Regeneron; grants from Gilead, Merck (BARDA); personal fees for consulting from Gilead, Eli Lilly; and non-financial support from Adaptive Biotechnologies and Labcorp/Monogram Biosciences outside the submitted work. Timothy Heinrich reported grant support from Merck Inc. and consulting fees from Roche. Rachel Hess reported serving as Data Safety Monitoring Board member for Astellas Pharmaceuticals unrelated to the current work. Leora Horwitz reported being a member of the National Academy of Medicine Committee on the Long-Term Health Effects Stemming from COVID-19 and Implications for the Social Security Administration. Priscilla Hsue reported receiving honoraria from Gilead and Merck unrelated to study topic, receiving study drug from Regeneron unrelated to study topic, and receiving a research grant from Novartis. Judith James reported OMRF has licensed her IP to Progentec Biosciences, has received grant support from Progentec Biosciences, and serves on Advisory Committees to Glaxo Smith Klein, Merck and Novartis. Arthur Kim reports providing educational materials to Clinical Care Options and UpToDate and serving on a Data Safety Monitoring board for Kintor Pharmaceuticals, Ltd. Bruce Levy reported serving as a consultant for AstraZeneca, Entrinsic Biosciences, Gossamer Bio and Nocion Therapeutics and receiving research support from Amgen, Genentech, GlaxoSmithKline, Pieris Pharmaceuticals, SRA and Sanofi unrelated to the current work. Vincent Marconi reported receiving grants from NIH during the conduct of the study and grants from NIH, Veteran Affairs, and Centers for Disease Control and Prevention; grants, personal fees, nonfinancial support, and other from Lilly and Gilead; grants and personal fees from ViiV; and nonfinancial support from Bayer outside the submitted work. Grace McComsey reported serving as consultant for Merck, Gilead, ViiV, Janssen and have received research support from Pfizer, Vanda, Genentech, Roche, Redhill and Cognivue. Torri Metz reported being a site PI and a participant in the medical advisory board for the planning of a Pfizer clinical trial of SARS-CoV-2 vaccination in pregnancy. She also reported being a site PI for a Pfizer study evaluating the pharmacokinetics of Paxlovid in pregnant people with COVID-19. Janet Mullington reported support for investigator-initiated research by "Open Medicine Foundation and the Patient-Led Research Collaborative" Princess Ogbogu reported research support from Astrazeneca, GSK, Blueprint medical; advisory board for Astrazeneca, GSK, Sanofi, Kalvista; and consulting for Astrazeneca, GSK Sairam Parthasarathy reported research funding to Institution from Sergey Brin foundation of COVID and Long-COVID research. Michael Peluso reported consulting fees from Gilead Sciences and AstraZeneca, and service on data safety monitoring board for American Gene Technologies. Sean Quigley reported service on speaker Board for Servier, Alnylam, Agios; service on advisory board for Recordati, Alexion. Franz Rischard reported research support from NIH/NHLBI, United Therapeutics, Acceleron/Merck, Janssen, Insmed, Aerovate, and Bayer; and consulting/advisory compensation from Acceleron and Bayer. Nadine Rouphael reported being a consultant for ICON and EMMES as a safety consultant for clinical trials; service on the advisory boards for Moderna; funds to institution from Sanofi, Lilly, Merck, Quidel and Pfizer. PJ Utz reported stock ownership of Gilead and PI of biomarker studies for Pfizer STOP-PASC paxlovid trial Juan Wisnivesky received receiving consulting honorarium from Sanofi, Banook, Prospero, PPD and Atea and research grants from Sanofi, Regeneron, Axella, and Arnold Consultants.
(Copyright: © 2023 Horwitz et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)