학술논문
Language impairments in Alzheimer´s disease: What changes can be found between mild and moderate stages of the disease?
Document Type
Academic Journal
Author
Ortiz KZ; Department of Speech, Language and Hearing Sciences, Universidade Federal de São Paulo, São Paulo, SP, Brazil. Electronic address: karin.ortiz@unifesp.br.; De Lira JO; Universidade de Brasília, Cinelândia Campus, Brasília, DF, Brazil.; Minett TSC; Department of Radiology, University of Cambridge, Cambridge, UK.; Bertolucci PHF; Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Source
Publisher: Elsevier Country of Publication: United States NLM ID: 101244734 Publication Model: eCollection Cited Medium: Internet ISSN: 1980-5322 (Electronic) Linking ISSN: 18075932 NLM ISO Abbreviation: Clinics (Sao Paulo) Subsets: MEDLINE
Subject
Language
English
Abstract
Objective: To investigate how language deteriorates over the Alzheimer's Disease course.
Methods: A cross-sectional, observational study was carried out. 35 patients diagnosed with dementia due to AD using the NINCDS-ARDRA criteria and undergoing treatment for AD with a therapeutic dose of acetylcholinesterase inhibitors were assessed by the Boston Diagnostic Aphasia Examination (BDAE). The sample comprised 15 patients with mild AD (MMSE > 23, CDR = 0 or 0.5‒1.0) and 20 patients with moderate AD (MMSE = 13‒23, CDR = 2). The results for the 2 groups on all language tasks were compared.
Results: A statistically significant difference was found between the mild and moderate AD groups for total score on the BDAE (95% CI 47.10‒114.08, t = 5.0, DF = 21, p = 0.000*), as well as on several tasks involving oral and writing comprehension, language oral expression and writing.
Conclusion: The study results showed major changes in the moderate stage. Also, the decline in language performance correlated with the worsening of dementia syndrome, independently of sociodemographic variables.
Competing Interests: Declaration of competing interest The authors declare no conflicts of interest.
(Copyright © 2024 HCFMUSP. Published by Elsevier España, S.L.U. All rights reserved.)
Methods: A cross-sectional, observational study was carried out. 35 patients diagnosed with dementia due to AD using the NINCDS-ARDRA criteria and undergoing treatment for AD with a therapeutic dose of acetylcholinesterase inhibitors were assessed by the Boston Diagnostic Aphasia Examination (BDAE). The sample comprised 15 patients with mild AD (MMSE > 23, CDR = 0 or 0.5‒1.0) and 20 patients with moderate AD (MMSE = 13‒23, CDR = 2). The results for the 2 groups on all language tasks were compared.
Results: A statistically significant difference was found between the mild and moderate AD groups for total score on the BDAE (95% CI 47.10‒114.08, t = 5.0, DF = 21, p = 0.000*), as well as on several tasks involving oral and writing comprehension, language oral expression and writing.
Conclusion: The study results showed major changes in the moderate stage. Also, the decline in language performance correlated with the worsening of dementia syndrome, independently of sociodemographic variables.
Competing Interests: Declaration of competing interest The authors declare no conflicts of interest.
(Copyright © 2024 HCFMUSP. Published by Elsevier España, S.L.U. All rights reserved.)