학술논문
The Relationship Between Potential Occupational Sensitizing Exposures and Asthma: An Overview of Systematic Reviews.
Document Type
Academic Journal
Author
Dalbøge A; Department of Occupational Medicine, Danish Ramazzini Centre, Aarhus University Hospital, 8200 Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, 8200 Aarhus, Denmark.; Albert Kolstad H; Department of Occupational Medicine, Danish Ramazzini Centre, Aarhus University Hospital, 8200 Aarhus, Denmark.; Ulrik CS; Department of Respiratory Medicine, Hvidovre University Hospital, 2650 Hvidovre, Denmark.; Sherson DL; Department of Occupational and Environmental Medicine, Odense University Hospital, 5000 Odense, Denmark.; Department of Pulmonary Medicine, Odense University Hospital, 5000 Odense, Denmark.; Meyer HW; Department of Occupational and Environmental Medicine, Bispebjerg and Frederiksberg Hospital, 2400 Copenhagen, Denmark.; Ebbehøj N; Department of Occupational and Environmental Medicine, Bispebjerg and Frederiksberg Hospital, 2400 Copenhagen, Denmark.; Sigsgaard T; Department of Public Health, Environment, Occupation, and Health, Danish Ramazzini Centre, Aarhus University, 8000 Aarhus, Denmark.; Zock JP; National Institute for Public Health and the Environment (RIVM), Bilthoven, 3721 MA, The Netherlands.; Baur X; Institut für Arbeitsmedizin, Charité Universitätsmedizin Berlin, 10117 Berlin, Germany.; Schlünssen V; National Research Centre for the Working Environment, 2100 Copenhagen, Denmark.; Department of Public Health, Environment, Occupation, and Health, Danish Ramazzini Centre, Aarhus University, 8000 Aarhus, Denmark.
Source
Publisher: Oxford University Press Country of Publication: England NLM ID: 101698454 Publication Model: Print Cited Medium: Internet ISSN: 2398-7316 (Electronic) Linking ISSN: 23987308 NLM ISO Abbreviation: Ann Work Expo Health Subsets: MEDLINE
Subject
Language
English
Abstract
Objectives: The aim was to identify, appraise, and synthesize the scientific evidence of the relationship between potential occupational sensitizing exposures and the development of asthma based on systematic reviews.
Methods: The study was conducted as an overview of systematic reviews. A systematic literature search was conducted for systematic reviews published up to 9 February 2020. Eligibility study criteria included persons in or above the working age, potential occupational sensitizing exposures, and outcomes defined as asthma. Potential occupational sensitizing exposures were divided into 23 main groups comprising both subgroups and specific exposures. Two reviewers independently selected studies, extracted study data, assessed study quality, and evaluated confidence in study results and level of evidence of the relationship between potential occupational sensitizing exposures and asthma.
Results: Twenty-seven systematic reviews were included covering 1242 studies and 486 potential occupational sensitizing exposures. Overall confidence in study results was rated high in three systematic reviews, moderate in seven reviews, and low in 17 reviews. Strong evidence for the main group of wood dusts and moderate evidence for main groups of mites and fish was found. For subgroups/specific exposures, strong evidence was found for toluene diisocyanates, Aspergillus, Cladosporium, Penicillium, and work tasks involving exposure to laboratory animals, whereas moderate evidence was found for 52 subgroups/specific exposures.
Conclusions: This overview identified hundreds of potential occupational sensitizing exposures suspected to cause asthma and evaluated the level of evidence for each exposure. Strong evidence was found for wood dust in general and for toluene diisocyanates, Aspergillus, Cladosporium, Penicillium, and work tasks involving exposure to laboratory animals.
(© The Author(s) 2022. Published by Oxford University Press on behalf of the British Occupational Hygiene Society.)
Methods: The study was conducted as an overview of systematic reviews. A systematic literature search was conducted for systematic reviews published up to 9 February 2020. Eligibility study criteria included persons in or above the working age, potential occupational sensitizing exposures, and outcomes defined as asthma. Potential occupational sensitizing exposures were divided into 23 main groups comprising both subgroups and specific exposures. Two reviewers independently selected studies, extracted study data, assessed study quality, and evaluated confidence in study results and level of evidence of the relationship between potential occupational sensitizing exposures and asthma.
Results: Twenty-seven systematic reviews were included covering 1242 studies and 486 potential occupational sensitizing exposures. Overall confidence in study results was rated high in three systematic reviews, moderate in seven reviews, and low in 17 reviews. Strong evidence for the main group of wood dusts and moderate evidence for main groups of mites and fish was found. For subgroups/specific exposures, strong evidence was found for toluene diisocyanates, Aspergillus, Cladosporium, Penicillium, and work tasks involving exposure to laboratory animals, whereas moderate evidence was found for 52 subgroups/specific exposures.
Conclusions: This overview identified hundreds of potential occupational sensitizing exposures suspected to cause asthma and evaluated the level of evidence for each exposure. Strong evidence was found for wood dust in general and for toluene diisocyanates, Aspergillus, Cladosporium, Penicillium, and work tasks involving exposure to laboratory animals.
(© The Author(s) 2022. Published by Oxford University Press on behalf of the British Occupational Hygiene Society.)