학술논문
When the cold gets under your skin: Evidence for brown adipose tissue activity in Samoan adults.
Document Type
Academic Journal
Author
Niclou A; Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.; Department of Anthropology, University of Notre Dame, Notre Dame, Indiana, USA.; Vesi L; Obesity, Lifestyle and Genetic Adaptations (OLaGA) Study Group, Apia, Samoa.; Arorae M; Obesity, Lifestyle and Genetic Adaptations (OLaGA) Study Group, Apia, Samoa.; Naseri NC; Obesity, Lifestyle and Genetic Adaptations (OLaGA) Study Group, Apia, Samoa.; Faasalele Savusa K; Obesity, Lifestyle and Genetic Adaptations (OLaGA) Study Group, Apia, Samoa.; Naseri T; Samoa Ministry of Health, Apia, Samoa.; DeLany JP; AdventHealth Orlando, Translational Research Institute, Orlando, Florida, USA.; McGarvey ST; International Health Institute & Departments of Epidemiology and Anthropology, Brown University, Providence, Rhode Island, USA.; Rivara AC; Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut, USA.; Ocobock C; Department of Anthropology, University of Notre Dame, Notre Dame, Indiana, USA.; Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana, USA.
Source
Publisher: John Wiley & Sons Inc Country of Publication: United States NLM ID: 101770171 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2692-7691 (Electronic) Linking ISSN: 26927691 NLM ISO Abbreviation: Am J Biol Anthropol Subsets: MEDLINE
Subject
Language
English
Abstract
Objectives: Brown adipose tissue (BAT) is a heat-producing organ aiding nonshivering thermogenesis (NST) during cold stress. Due to its potential cold-adaptive role BAT has been predominantly studied in cold and temperate climate populations, but not among warm-climate adults. This work explores if BAT activity can be inferred in Samoans.
Materials and Methods: We inferred BAT activity by comparing metabolic rate and surface heat dissipation using indirect calorimetry and thermal imaging between room temperature and cold exposure among Samoans (N = 61, females: n = 38) from 'Upolu Island, Samoa. BAT activity was inferred using ANOVA linear regression models with the variables measured at cold exposure as outcomes. T-tests were used to compare changes in surface temperature between room temperature and cold exposure.
Results: Metabolic rate significantly increased after cooling. In both the supraclavicular area, a known BAT location, and the sternum, a non-BAT location, temperatures decreased significantly upon cold exposure. Differences in supraclavicular temperatures between room temperature and cold were significantly smaller than differences in sternum temperatures between exposures. These results suggest that BAT thermogenesis occurred in known BAT-locations and thus contributed to NST during cooling.
Conclusions: This study adds to our understanding of BAT activity across different populations and climates. Further study may illuminate whether the cold-adaptive properties of BAT may have played a role in the successful expansion of populations across the globe, including warm-climate groups.
(© 2023 Wiley Periodicals LLC.)
Materials and Methods: We inferred BAT activity by comparing metabolic rate and surface heat dissipation using indirect calorimetry and thermal imaging between room temperature and cold exposure among Samoans (N = 61, females: n = 38) from 'Upolu Island, Samoa. BAT activity was inferred using ANOVA linear regression models with the variables measured at cold exposure as outcomes. T-tests were used to compare changes in surface temperature between room temperature and cold exposure.
Results: Metabolic rate significantly increased after cooling. In both the supraclavicular area, a known BAT location, and the sternum, a non-BAT location, temperatures decreased significantly upon cold exposure. Differences in supraclavicular temperatures between room temperature and cold were significantly smaller than differences in sternum temperatures between exposures. These results suggest that BAT thermogenesis occurred in known BAT-locations and thus contributed to NST during cooling.
Conclusions: This study adds to our understanding of BAT activity across different populations and climates. Further study may illuminate whether the cold-adaptive properties of BAT may have played a role in the successful expansion of populations across the globe, including warm-climate groups.
(© 2023 Wiley Periodicals LLC.)