학술논문
LDL particle size and composition and incident cardiovascular disease in a South-European population: The Hortega-Liposcale Follow-up Study.
Document Type
Academic Journal
Author
Pichler G; Cardiometabolic and Renal Risk, Biomedical Research Institute INCLIVA, Valencia, Spain; Department of Internal Medicine, Hospital Clinic of Valencia, University of Valencia, Spain.; Amigo N; Biosfer Teslab, Reus, Spain; Metabolomics platform, Rovira i Virgili University, Tarragona, Spain; Intitut d'Investigació Sanitària Pere i Virgili (IISPV), Reus, Spain.; Tellez-Plaza M; Cardiometabolic and Renal Risk, Biomedical Research Institute INCLIVA, Valencia, Spain; Departments of Environmental Health Sciences, Medicine, and Epidemiology, Johns Hopkins Medical Institutions, Baltimore, USA.; Pardo-Cea MA; Biosfer Teslab, Reus, Spain.; Dominguez-Lucas A; Cardiometabolic and Renal Risk, Biomedical Research Institute INCLIVA, Valencia, Spain.; Marrachelli VG; Metabolomic and Molecular Image Lab, Biomedical Research Institute INCLIVA, Valencia, Spain.; Monleon D; Metabolomic and Molecular Image Lab, Biomedical Research Institute INCLIVA, Valencia, Spain.; Martin-Escudero JC; Department of Internal Medicine, University Hospital Rio Hortega, Valladolid, Spain.; Ascaso JF; Department of Internal Medicine, Hospital Clinic of Valencia, University of Valencia, Spain; CIBER of Diabetes and Associated Metabolic Diseases (CIBERDEM), Institute of Health Carlos III, Madrid, Spain.; Chaves FJ; CIBER of Diabetes and Associated Metabolic Diseases (CIBERDEM), Institute of Health Carlos III, Madrid, Spain.; Carmena R; Department of Internal Medicine, Hospital Clinic of Valencia, University of Valencia, Spain; CIBER of Diabetes and Associated Metabolic Diseases (CIBERDEM), Institute of Health Carlos III, Madrid, Spain.; Redon J; Cardiometabolic and Renal Risk, Biomedical Research Institute INCLIVA, Valencia, Spain; Department of Internal Medicine, Hospital Clinic of Valencia, University of Valencia, Spain; CIBER 03/06 Physiopathology of Obesity and Nutrition (CIBEROBN), Institute of Health Carlos III, Madrid, Spain. Electronic address: josep.redon@uv.es.
Source
Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8200291 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1874-1754 (Electronic) Linking ISSN: 01675273 NLM ISO Abbreviation: Int J Cardiol Subsets: MEDLINE
Subject
Language
English
Abstract
Background: The association of low-density lipoprotein (LDL) particle composition with cardiovascular risk has not been explored before. The aim was to evaluate the relationship between baseline LDL particle size and composition (proportions of large, medium and small LDL particles over their sum expressed as small-LDL %, medium-LDL % and large-LDL %) and incident cardiovascular disease in a population-based study.
Methods: Direct measurement of LDL particles was performed using a two-dimensional NMR-technique (Liposcale®). LDL cholesterol was assessed using both standard photometrical methods and the Liposcale® technique in a representative sample of 1162 adult men and women from Spain.
Results: The geometric mean of total LDL particle concentration in the study sample was 827.2 mg/dL (95% CI 814.7, 839.8). During a mean follow-up of 12.4 ± 3.3 years, a total of 159 events occurred. Medium LDL particles were positively associated with all cardiovascular disease, coronary heart disease (CHD) and stroke after adjustment for traditional risk factors and treatment. Regarding LDL particle composition, the multivariable adjusted hazard ratios for CHD for a 5% increase in medium and small LDL % by a corresponding decrease of large LDL % were 1.93 (1.55, 2.39) and 1.41 (1.14, 1.74), respectively.
Conclusions: Medium LDL particles were associated with incident cardiovascular disease. LDL particles showed the strongest association with cardiovascular events when the particle composition, rather than the total concentration, was investigated. A change in baseline composition of LDL particles from large to medium and small LDL particles was associated with an increased cardiovascular risk, especially for CHD.
(Copyright © 2018 Elsevier B.V. All rights reserved.)
Methods: Direct measurement of LDL particles was performed using a two-dimensional NMR-technique (Liposcale®). LDL cholesterol was assessed using both standard photometrical methods and the Liposcale® technique in a representative sample of 1162 adult men and women from Spain.
Results: The geometric mean of total LDL particle concentration in the study sample was 827.2 mg/dL (95% CI 814.7, 839.8). During a mean follow-up of 12.4 ± 3.3 years, a total of 159 events occurred. Medium LDL particles were positively associated with all cardiovascular disease, coronary heart disease (CHD) and stroke after adjustment for traditional risk factors and treatment. Regarding LDL particle composition, the multivariable adjusted hazard ratios for CHD for a 5% increase in medium and small LDL % by a corresponding decrease of large LDL % were 1.93 (1.55, 2.39) and 1.41 (1.14, 1.74), respectively.
Conclusions: Medium LDL particles were associated with incident cardiovascular disease. LDL particles showed the strongest association with cardiovascular events when the particle composition, rather than the total concentration, was investigated. A change in baseline composition of LDL particles from large to medium and small LDL particles was associated with an increased cardiovascular risk, especially for CHD.
(Copyright © 2018 Elsevier B.V. All rights reserved.)