학술논문
Early in vivo detection of denervation-induced atrophy by luminescence transient nanothermometry.
Document Type
Academic Journal
Author
Lifante J; Facultad de Medicina, Departamento de Fisiología, Nanomaterials for Bioimaging Group (NanoBIG), Universidad Autónoma de Madrid, Madrid, Spain.; Nanomaterials for Bioimaging Group (NanoBIG), Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain.; Moreno-Rupérez Á; Facultad de Medicina, Departamento de Fisiología, Universidad Complutense de Madrid, Madrid, Spain.; Ximendes E; Nanomaterials for Bioimaging Group (NanoBIG), Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain.; Departamento de Física de Materiales, Facultad de Ciencias, Nanomaterials for Bioimaging Group (NanoBIG), Universidad Autónoma de Madrid, Madrid, Spain.; Marin R; Nanomaterials for Bioimaging Group (NanoBIG), Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain.; Departamento de Física de Materiales, Facultad de Ciencias, Nanomaterials for Bioimaging Group (NanoBIG), Universidad Autónoma de Madrid, Madrid, Spain.; Institute for Advanced Research in Chemical Sciences (IAdChem), Autonomous University of Madrid, Madrid, Spain.; Priego T; Facultad de Enfermería, Fisioterapia y Podología, Departamento de Fisiología, Universidad Complutense de Madrid, Madrid, Spain.; López-Calderón A; Facultad de Medicina, Departamento de Fisiología, Universidad Complutense de Madrid, Madrid, Spain.; Martín AI; Facultad de Medicina, Departamento de Fisiología, Universidad Complutense de Madrid, Madrid, Spain.; Nieto-Bona MP; Facultad de Ciencias de la Salud, Departamento de Ciencias Básicas, Universidad Rey Juan Carlos, Madrid, Spain.; Nebot E; Facultad de Medicina, Departamento de Fisiología, Universidad Complutense de Madrid, Madrid, Spain.; Lifante-Pedrola G; Departamento de Física de Materiales, Facultad de Ciencias, Nanomaterials for Bioimaging Group (NanoBIG), Universidad Autónoma de Madrid, Madrid, Spain.; Jaque D; Nanomaterials for Bioimaging Group (NanoBIG), Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain.; Departamento de Física de Materiales, Facultad de Ciencias, Nanomaterials for Bioimaging Group (NanoBIG), Universidad Autónoma de Madrid, Madrid, Spain.; Institute for Advanced Research in Chemical Sciences (IAdChem), Autonomous University of Madrid, Madrid, Spain.; Monge L; Facultad de Medicina, Departamento de Fisiología, Nanomaterials for Bioimaging Group (NanoBIG), Universidad Autónoma de Madrid, Madrid, Spain.; Nanomaterials for Bioimaging Group (NanoBIG), Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain.; Fernández N; Facultad de Medicina, Departamento de Fisiología, Nanomaterials for Bioimaging Group (NanoBIG), Universidad Autónoma de Madrid, Madrid, Spain.; Nanomaterials for Bioimaging Group (NanoBIG), Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain.; Granado M; Facultad de Medicina, Departamento de Fisiología, Nanomaterials for Bioimaging Group (NanoBIG), Universidad Autónoma de Madrid, Madrid, Spain.; Nanomaterials for Bioimaging Group (NanoBIG), Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain.
Source
Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101318567 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1864-0648 (Electronic) Linking ISSN: 1864063X NLM ISO Abbreviation: J Biophotonics Subsets: MEDLINE
Subject
Language
English
Abstract
Denervation induces skeletal muscle atrophy due to the loss of control and feedback with the nervous system. Unfortunately, muscle atrophy only becomes evident days after the denervation event when it could be irreversible. Alternative diagnosis tools for early detection of denervation-induced muscle atrophy are, thus, required. In this work, we demonstrate how the combination of transient thermometry, a technique already used for early diagnosis of tumors, and infrared-emitting nanothermometers makes possible the in vivo detection of the onset of muscle atrophy at short (<1 day) times after a denervation event. The physiological reasons behind these experimental results have been explored by performing three dimensional numerical simulations based on the Pennes' bioheat equation. It is concluded that the alterations in muscle thermal dynamics at the onset of muscle atrophy are consequence of the skin perfusion increment caused by the alteration of peripheral nervous autonomous system. This work demonstrates the potential of infrared luminescence thermometry for early detection of diseases of the nervous system opening the venue toward the development of new diagnosis tools.
(© 2023 The Authors. Journal of Biophotonics published by Wiley-VCH GmbH.)
(© 2023 The Authors. Journal of Biophotonics published by Wiley-VCH GmbH.)