학술논문
Human infection with a zoonotic orthopoxvirus in the country of Georgia.
Document Type
Academic Journal
Author
Vora NM; From the Epidemic Intelligence Service (N.M.V.), Division of High-Consequence Pathogens and Pathology (N.M.V., Y.L., G.L.E., P.S.S., N.G.-R., C.S.G., M.G.M., I.D., M.G.R., D.S.C.), and the Division of Global Health Protection (N.M.V., M.G., E.F.M., J.M.), Centers for Disease Control and Prevention (CDC), Atlanta; CDC Georgia Country Office (M.G., J.M.), National Center for Disease Control and Public Health (E.K., A.N., K.Z.), Laboratory of the Ministry of Agriculture (G. Maghlakelidze, M.K.), and Infectious Diseases, AIDS, and Clinical Immunology Research Center (M.E.), Tbilisi, and National Food Agency, Tianeti (G. Mokverashvili) - all in Georgia.; Li Y; Geleishvili M; Emerson GL; Khmaladze E; Maghlakelidze G; Navdarashvili A; Zakhashvili K; Kokhreidze M; Endeladze M; Mokverashvili G; Satheshkumar PS; Gallardo-Romero N; Goldsmith CS; Metcalfe MG; Damon I; Maes EF; Reynolds MG; Morgan J; Carroll DS
Source
Publisher: Massachusetts Medical Society Country of Publication: United States NLM ID: 0255562 Publication Model: Print Cited Medium: Internet ISSN: 1533-4406 (Electronic) Linking ISSN: 00284793 NLM ISO Abbreviation: N Engl J Med Subsets: MEDLINE
Subject
Language
English
Abstract
During 2013, cutaneous lesions developed in two men in the country of Georgia after they were exposed to ill cows. The men had never received vaccination against smallpox. Tests of lesion material with the use of a quantitative real-time polymerase-chain-reaction assay for non-variola virus orthopoxviruses were positive, and DNA sequence analysis implicated a novel orthopoxvirus species. During the ensuing epidemiologic investigation, no additional human cases were identified. However, serologic evidence of exposure to an orthopoxvirus was detected in cows in the patients' herd and in captured rodents and shrews. A third case of human infection that occurred in 2010 was diagnosed retrospectively during testing of archived specimens that were originally submitted for tests to detect anthrax. Orthopoxvirus infection should be considered in persons in whom cutaneous lesions develop after contact with animals.