학술논문
Microstructural abnormalities are evident by histology but not HR-pQCT at the periosteal cortex of the human tibia under CVD and T2D conditions.
Document Type
Academic Journal
Author
Garita B; Department of Radiology and Biomedical Imaging, University of California, San Francisco, 185 Berry St Suite 350, San Francisco, CA, 94107, USA.; Maligro J; Department of Radiology and Biomedical Imaging, University of California, San Francisco, 185 Berry St Suite 350, San Francisco, CA, 94107, USA.; Sadoughi S; Department of Radiology and Biomedical Imaging, University of California, San Francisco, 185 Berry St Suite 350, San Francisco, CA, 94107, USA.; Wu PH; Department of Radiology and Biomedical Imaging, University of California, San Francisco, 185 Berry St Suite 350, San Francisco, CA, 94107, USA.; Liebenberg E; Department of Orthopaedic Surgery, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA, 94143, USA.; Horvai A; Department of Pathology, University of California, San Francisco, 1825 4th St, San Francisco, CA, 94143, USA.; Link TM; Department of Radiology and Biomedical Imaging, University of California, San Francisco, 185 Berry St Suite 350, San Francisco, CA, 94107, USA.; Kazakia GJ; Department of Radiology and Biomedical Imaging, University of California, San Francisco, 185 Berry St Suite 350, San Francisco, CA, 94107, USA.
Source
Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101771185 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2590-0935 (Electronic) Linking ISSN: 25900935 NLM ISO Abbreviation: Med Nov Technol Devices Subsets: PubMed not MEDLINE
Subject
Language
English
Abstract
Cortical bone microstructure deficits may increase fracture risk in individuals with cardiovascular disease and diabetes. High resolution peripheral quantitative computed tomography (HR-pQCT) enables in vivo microstructure characterization but is limited in its ability to visualize important biological features. We conducted histological analyses and HR-pQCT imaging of distal tibia bone samples from 6 donors with cardiovascular disease (CVD) and type 2 diabetes mellitus (T2D). Histology but not HR-pQCT identified previously undocumented morphopathological deficits that may contribute to cortical bone fragility. These observations may provide guidance for improved HR-pQCT microstructural characterization as well as insight into mechanisms of cortical bone degradation.
Competing Interests: Declaration of competing interest The authors declare that there are no conflicts of interest.
Competing Interests: Declaration of competing interest The authors declare that there are no conflicts of interest.