학술논문
Advances in hyaluronic acid production: Biosynthesis and genetic engineering strategies based on Streptococcus - A review.
Document Type
Academic Journal
Author
Wei M; College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310000, PR China.; Huang Y; College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310000, PR China.; Zhu J; College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310000, PR China.; Qiao Y; College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310000, PR China.; Xiao N; College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310000, PR China.; Jin M; College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310000, PR China.; Gao H; College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310000, PR China.; Huang Y; College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310000, PR China.; Hu X; College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310000, PR China.; Li O; College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310000, PR China. Electronic address: ouli@zstu.edu.cn.
Source
Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE
Subject
Language
English
Abstract
Hyaluronic acid (HA), which is a highly versatile glycosaminoglycan, is widely applied across the fields of food, cosmetics, and pharmaceuticals. It is primary produced through Streptococcus fermentation, but the product presents inherent challenges concerning consistency and potential pathogenicity. However, recent strides in molecular biology have paved the way for genetic engineering, which facilitates the creation of high-yield, nonpathogenic strains adept at synthesizing HA with specific molecular weights. This comprehensive review extensively explores the molecular biology underpinning pivotal HA synthase genes, which elucidates the intricate mechanisms governing HA synthesis. Moreover, it delineates various strategies employed in engineering HA-producing strains.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)