학술논문
The Role of PTEN in Innate and Adaptive Immunity.
Document Type
Academic Journal
Author
Taylor H; Department of Surgery and Cancer, Imperial College London, London SW7 2AZ, United Kingdom.; Laurence ADJ; Translational Gastroenterology Unit, NIHR Oxford Biomedical Research Centre, Nuffield Department of Experimental Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom.; Department of Haematology, University College London Hospitals NHS Trust, London WC1E 6AG, United Kingdom.; Uhlig HH; Translational Gastroenterology Unit, NIHR Oxford Biomedical Research Centre, Nuffield Department of Experimental Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom.; Department of Paediatrics, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom.; NIHR Oxford Biomedical Research Centre, Oxford OX3 9DU, United Kingdom.
Source
Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 101571139 Publication Model: Electronic Cited Medium: Internet ISSN: 2157-1422 (Electronic) Linking ISSN: 21571422 NLM ISO Abbreviation: Cold Spring Harb Perspect Med Subsets: MEDLINE
Subject
Language
English
Abstract
The lipid and protein phosphatase and tensin homolog (PTEN) controls the differentiation and activation of multiple immune cells. PTEN acts downstream from T- and B-cell receptors, costimulatory molecules, cytokine receptors, integrins, and also growth factor receptors. Loss of PTEN activity in human and mice is associated with cellular and humoral immune dysfunction, lymphoid hyperplasia, and autoimmunity. Although most patients with PTEN hamartoma tumor syndrome (PHTS) have no immunological symptoms, a subclinical immune dysfunction is present in many, and clinical immunodeficiency in few. Comparison of the immune phenotype caused by PTEN haploinsufficiency in PHTS, phosphoinositide 3-kinase (PI3K) gain-of-function in activated PI3K syndrome, and mice with conditional biallelic Pten deletion suggests a threshold model in which coordinated activity of several phosphatases control the PI3K signaling in a cell-type-specific manner. Emerging evidence highlights the role of PTEN in polygenic autoimmune disorders, infection, and the immunological response to cancer. Targeting the PI3K axis is an emerging therapeutic avenue.
(Copyright © 2019 Cold Spring Harbor Laboratory Press; all rights reserved.)
(Copyright © 2019 Cold Spring Harbor Laboratory Press; all rights reserved.)