학술논문
Emerging variants develop total escape from potent monoclonal antibodies induced by BA.4/5 infection.
Document Type
Academic Journal
Author
Liu C; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK.; Nuffield Department of Medicine, Centre for Human Genetics, University of Oxford, Oxford, UK.; Das R; Nuffield Department of Medicine, Centre for Human Genetics, University of Oxford, Oxford, UK.; Dijokaite-Guraliuc A; Nuffield Department of Medicine, Centre for Human Genetics, University of Oxford, Oxford, UK.; Zhou D; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK.; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Oxford, UK.; College of Life Sciences, Zhejiang University, Hangzhou, 310058, China.; Mentzer AJ; Nuffield Department of Medicine, Centre for Human Genetics, University of Oxford, Oxford, UK.; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; Supasa P; Nuffield Department of Medicine, Centre for Human Genetics, University of Oxford, Oxford, UK.; Selvaraj M; Nuffield Department of Medicine, Centre for Human Genetics, University of Oxford, Oxford, UK.; Duyvesteyn HME; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Oxford, UK.; Ritter TG; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; Temperton N; Viral Pseudotype Unit, Medway School of Pharmacy, University of Kent and Greenwich Chatham Maritime, Kent, ME4 4TB, UK.; Klenerman P; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; Peter Medawar Building for Pathogen Research, Oxford, UK.; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.; NIHR Oxford Biomedical Research Centre, Oxford, UK.; Dunachie SJ; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; Peter Medawar Building for Pathogen Research, Oxford, UK.; Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK.; Mahidol-Oxford Tropical Medicine Research Unit, Bangkok, Thailand.; Paterson NG; Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK.; Williams MA; Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK.; Hall DR; Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK.; Fry EE; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Oxford, UK. liz@strubi.ox.ac.uk.; Mongkolsapaya J; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK. juthathip.mongkolsapaya@well.ox.ac.uk.; Nuffield Department of Medicine, Centre for Human Genetics, University of Oxford, Oxford, UK. juthathip.mongkolsapaya@well.ox.ac.uk.; Mahidol-Oxford Tropical Medicine Research Unit, Bangkok, Thailand. juthathip.mongkolsapaya@well.ox.ac.uk.; Ren J; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Oxford, UK. ren@strubi.ox.ac.uk.; Stuart DI; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK. dave@strubi.ox.ac.uk.; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Oxford, UK. dave@strubi.ox.ac.uk.; Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK. dave@strubi.ox.ac.uk.; Screaton GR; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK. gavin.screaton@medsci.ox.ac.uk.; Nuffield Department of Medicine, Centre for Human Genetics, University of Oxford, Oxford, UK. gavin.screaton@medsci.ox.ac.uk.
Source
Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Subject
Language
English
Abstract
The rapid evolution of SARS-CoV-2 is driven in part by a need to evade the antibody response in the face of high levels of immunity. Here, we isolate spike (S) binding monoclonal antibodies (mAbs) from vaccinees who suffered vaccine break-through infections with Omicron sub lineages BA.4 or BA.5. Twenty eight potent antibodies are isolated and characterised functionally, and in some cases structurally. Since the emergence of BA.4/5, SARS-CoV-2 has continued to accrue mutations in the S protein, to understand this we characterize neutralization of a large panel of variants and demonstrate a steady attrition of neutralization by the panel of BA.4/5 mAbs culminating in total loss of function with recent XBB.1.5.70 variants containing the so-called 'FLip' mutations at positions 455 and 456. Interestingly, activity of some mAbs is regained on the recently reported variant BA.2.86.
(© 2024. The Author(s).)
(© 2024. The Author(s).)