학술논문
Atractylodes macrocephala Koidz Alleviates Symptoms in Zymosan-Induced Irritable Bowel Syndrome Mouse Model through TRPV1, NaV1.5, and NaV1.7 Channel Modulation.
Document Type
Academic Journal
Author
Choi NR; Department of Longevity and Biofunctional Medicine, School of Korean Medicine, Pusan National University, Yangsan 50612, Republic of Korea.; Department of Korean Medical Science, School of Korean Medicine, Pusan National University, Yangsan 50612, Republic of Korea.; Choi WG; Department of Longevity and Biofunctional Medicine, School of Korean Medicine, Pusan National University, Yangsan 50612, Republic of Korea.; Lee JH; Department of Biomedical Engineering, College of Engineering, Dong-Eui University, Busan 47340, Republic of Korea.; Park J; Division of Food Functionality, Korea Food Research Institute, Wanju-gun 55365, Republic of Korea.; Department of Food Biotechnology, Korea University of Science & Technology, Daejeon 34113, Republic of Korea.; Kim YT; Division of Food Functionality, Korea Food Research Institute, Wanju-gun 55365, Republic of Korea.; Department of Food Biotechnology, Korea University of Science & Technology, Daejeon 34113, Republic of Korea.; Das R; Department of Physiology, College of Medicine, Dongguk University, Gyeongju 38066, Republic of Korea.; Woo JH; Department of Physiology, College of Medicine, Dongguk University, Gyeongju 38066, Republic of Korea.; Kim BJ; Department of Longevity and Biofunctional Medicine, School of Korean Medicine, Pusan National University, Yangsan 50612, Republic of Korea.
Source
Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE
Subject
Language
English
Abstract
(1) Background: Irritable bowel syndrome (IBS) is a common disease in the gastrointestinal (GI) tract. Atractylodes macrocephala Koidz (AMK) is known as one of the traditional medicines that shows a good efficacy in the GI tract. (2) Methods: We investigated the effect of AMK in a network pharmacology and zymosan-induced IBS animal model. In addition, we performed electrophysiological experiments to confirm the regulatory mechanisms related to IBS. (3) Results: Various characteristics of AMK were investigated using TCMSP data and various analysis systems. AMK restored the macroscopic changes and weight to normal. Colonic mucosa and inflammatory factors were reduced. These effects were similar to those of amitriptyline and sulfasalazine. In addition, transient receptor potential (TRP) V1, voltage-gated Na + (NaV) 1.5, and NaV1.7 channels were inhibited. (4) Conclusion: These results suggest that AMK may be a promising therapeutic candidate for IBS management through the regulation of ion channels.