학술논문
Occult hepatitis B infection in Turkish HIV-infected patients: A multicentre, retrospective, cross-sectional study, Schindler study.
Document Type
Academic Journal
Author
Ünlü G; Infectious Diseases and Clinical Microbiology Clinic, Kocaeli Derince Training and Research Hospital University of Health Science, Kocaeli, Turkey.; Yıldız Y; Department of Infectious Diseases and Clinical Microbiology, Gazi University Faculty of Medicine, Ankara, Turkey.; Ören MM; Department of Public Health, Istanbul University Istanbul Faculty of Medicine, Istanbul, Turkey.; Çabalak M; Department of Infectious Diseases and Clinical Microbiology, Mustafa Kemal University Medical Faculty, Hatay, Turkey.; Mete Ö; Department of Infectious Diseases and Clinical Microbiology, Gaziantep University Faculty of Medicine, Gaziantep, Turkey.; Kömür S; Department of Infectious Diseases and Clinical Microbiology, Çukurova University Medical Faculty, Adana, Turkey.; Yıldırım F; Clinic of Infectious Diseases and Clinical Microbiology, Antalya Training and Research Hospital, Antalya, Turkey.; İnan D; Department of Infectious Diseases and Clinical Microbiology, Akdeniz University Faculty of Medicine, Antalya, Turkey.; Altunışık Toplu S; Department of Infectious Diseases and Clinical Microbiology, İnönü University Medical Faculty, Malatya, Turkey.; Akhan S; Department of Infectious Diseases and Clinical Microbiology, Kocaeli University Faculty of Medicine, Kocaeli, Turkey.; Karaşahin Ö; Department of Infectious Diseases and Clinical Microbiology, Erzurum Regional Training and Research Hospital, Erzurum, Turkey.; Akdemir Kalkan İ; Department of Infectious Diseases and Clinical Microbiology, Ankara University Faculty of Medicine, Ankara, Turkey.; Demir Y; Department of Infectious Diseases and Clinical Microbiology, Dicle University Faculty of Medicine, Diyarbakır, Turkey.; Ayhan M; Self-Employed Pharmacists, Ela Pharmacy, Batman, Turkey.; Karaoğlan İ; Department of Infectious Diseases and Clinical Microbiology, Gaziantep University Faculty of Medicine, Gaziantep, Turkey.; Taşova Y; Department of Infectious Diseases and Clinical Microbiology, Çukurova University Medical Faculty, Adana, Turkey.; Bayındır Y; Department of Infectious Diseases and Clinical Microbiology, İnönü University Medical Faculty, Malatya, Turkey.; Dal T; Medical Microbiology Department, Ankara Yıldırım Beyazıt University Medical Faculty, Ankara, Turkey.; Çelen MK; Department of Infectious Diseases and Clinical Microbiology, Dicle University Faculty of Medicine, Diyarbakır, Turkey.
Source
Publisher: Hindawi Country of Publication: India NLM ID: 9712381 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1742-1241 (Electronic) Linking ISSN: 13685031 NLM ISO Abbreviation: Int J Clin Pract Subsets: MEDLINE
Subject
Language
English
Abstract
Objective: Occult hepatitis B infection (OHBI) appears to have a higher prevalence in populations at high risk for hepatitis B virus (HBV) infection with concomitant liver disease. The aim was to assess the prevalence of OHBI in a sample of human immunodeficiency virus -1 positive and HBV surface antigen-negative (HIV-1+/HBsAg-) Turkish patients.
Methods: Ten centres in Turkey were included in the study. Patients were selected on the basis of a power calculation with a known population size of HIV-positive patients and a reported prevalence of OHBI. Gender, age, occupation, place of residence, treatment and clinical status, and laboratory results, including immunodeficiency panel, antibody tests, hemogram, biochemistry, and coagulation studies were evaluated retrospectively.
Results: The number of HIV-infected patients followed in these centres was 3172 and the sample population numbered 278. All 278 were HBsAg negative. The mean age of the sample was 37.2 ± 13.1 years and 235 (84.5%) were male. All but one patient (99.6%) had been treated with antiretroviral therapy. Of the 278 patients, 169 (60.6%) were positive for Anti-HBs and 125 (44.8%) were positive for Anti-HBc IgG. HIV RNA was detected in 203/278 (73%) of the patients. Four HBV DNA (1.4%) were diagnosed with OHBI. There was no significant difference in hemogram, hemoglobin or bilirubin concentrations in those with OHBI compared with the other patients.
Conclusion: In a representative sample of HIV+ patients from 10 Turkish centres, the prevalence of OHBI was found to be 1.4%. In HIV positive patients, it is important to identify those with OHBI for optimal clinical management and prognosis.
(© 2021 John Wiley & Sons Ltd.)
Methods: Ten centres in Turkey were included in the study. Patients were selected on the basis of a power calculation with a known population size of HIV-positive patients and a reported prevalence of OHBI. Gender, age, occupation, place of residence, treatment and clinical status, and laboratory results, including immunodeficiency panel, antibody tests, hemogram, biochemistry, and coagulation studies were evaluated retrospectively.
Results: The number of HIV-infected patients followed in these centres was 3172 and the sample population numbered 278. All 278 were HBsAg negative. The mean age of the sample was 37.2 ± 13.1 years and 235 (84.5%) were male. All but one patient (99.6%) had been treated with antiretroviral therapy. Of the 278 patients, 169 (60.6%) were positive for Anti-HBs and 125 (44.8%) were positive for Anti-HBc IgG. HIV RNA was detected in 203/278 (73%) of the patients. Four HBV DNA (1.4%) were diagnosed with OHBI. There was no significant difference in hemogram, hemoglobin or bilirubin concentrations in those with OHBI compared with the other patients.
Conclusion: In a representative sample of HIV+ patients from 10 Turkish centres, the prevalence of OHBI was found to be 1.4%. In HIV positive patients, it is important to identify those with OHBI for optimal clinical management and prognosis.
(© 2021 John Wiley & Sons Ltd.)