학술논문
Cardiopulmonary exercise testing in adolescence following extremely premature birth.
Document Type
Academic Journal
Author
Amitai N; Pulmonary Institute, Schneider Children's Medical Center of Israel, Petah Tikva, Israel.; School of Medicine, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Stafler P; Pulmonary Institute, Schneider Children's Medical Center of Israel, Petah Tikva, Israel.; School of Medicine, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Blau H; Pulmonary Institute, Schneider Children's Medical Center of Israel, Petah Tikva, Israel.; School of Medicine, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Kaplan E; School of Medicine, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Pediatric Intensive Care Unit, Schneider Children's Medical Center of Israel, Petah Tikva, Israel.; Mussaffi H; Pulmonary Institute, Schneider Children's Medical Center of Israel, Petah Tikva, Israel.; School of Medicine, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Levine H; Pulmonary Institute, Schneider Children's Medical Center of Israel, Petah Tikva, Israel.; School of Medicine, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Bar-On O; Pulmonary Institute, Schneider Children's Medical Center of Israel, Petah Tikva, Israel.; School of Medicine, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Steuer G; Pulmonary Institute, Schneider Children's Medical Center of Israel, Petah Tikva, Israel.; Bar-Yishay E; Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheba, Israel.; Klinger G; School of Medicine, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Neonatal Intensive Care Unit, Schneider Children's Medical Center of Israel, Petah Tikva, Israel.; Mei-Zahav M; Pulmonary Institute, Schneider Children's Medical Center of Israel, Petah Tikva, Israel.; School of Medicine, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Prais D; Pulmonary Institute, Schneider Children's Medical Center of Israel, Petah Tikva, Israel.; School of Medicine, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Source
Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8510590 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1099-0496 (Electronic) Linking ISSN: 10990496 NLM ISO Abbreviation: Pediatr Pulmonol Subsets: MEDLINE
Subject
Language
English
Abstract
Background: Although extremely premature birth disrupts lung development, adolescent survivors of extreme prematurity show good clinical and physiologic outcomes. Cardiopulmonary limitations may not be clinically evident at rest. Data regarding exercise limitation in adolescents following preterm birth in the postsurfactant era are limited.
Research Question: What are the long-term effects of bronchopulmonary dysplasia (BPD) and extreme prematurity (<29 weeks) on ventilatory response during exercise in adolescents in the postsurfactant era?
Study Design and Methods: We followed a longitudinally recruited cohort of children aged 13-19 years who were born at a gestational age of <29 weeks (study group - SG). We compared the cardiopulmonary exercise testing (CPET) results of those with and without BPD, to their own CPET results from elementary school age (mean 9.09 ± 1.05 years).
Results: Thirty-seven children aged 15.73 ± 1.31 years, mean gestational age 26 weeks ( ± 1.19), completed the study. CPET parameters in adolescence were within the normal range for age, including mean V̇O2 peak of 91% predicted. The BPD and non-BPD subgroups had similar results. In the longitudinal analysis of the SG, improvement was observed in adolescence, compared with elementary school age, in breathing reserve (36.37 ± 18.99 vs. 26.58 ± 17.92, p = 0.044), tidal volume as a fraction of vital capacity achieved at maximal load (0.51 ± 0.13 vs. 0.37 ± 0.08, p < 0.001), and respiratory exchange ratio at maximal load (1.18 ± 0.13 vs. 1.11 ± 0.10, p = 0.021).
Interpretation: In the current cohort, adolescents born extremely premature have essentially normal ventilatory response during exercise, unrelated to BPD diagnosis. CPET results in this population improve over time.
(© 2024 The Authors. Pediatric Pulmonology published by Wiley Periodicals LLC.)
Research Question: What are the long-term effects of bronchopulmonary dysplasia (BPD) and extreme prematurity (<29 weeks) on ventilatory response during exercise in adolescents in the postsurfactant era?
Study Design and Methods: We followed a longitudinally recruited cohort of children aged 13-19 years who were born at a gestational age of <29 weeks (study group - SG). We compared the cardiopulmonary exercise testing (CPET) results of those with and without BPD, to their own CPET results from elementary school age (mean 9.09 ± 1.05 years).
Results: Thirty-seven children aged 15.73 ± 1.31 years, mean gestational age 26 weeks ( ± 1.19), completed the study. CPET parameters in adolescence were within the normal range for age, including mean V̇O
Interpretation: In the current cohort, adolescents born extremely premature have essentially normal ventilatory response during exercise, unrelated to BPD diagnosis. CPET results in this population improve over time.
(© 2024 The Authors. Pediatric Pulmonology published by Wiley Periodicals LLC.)