학술논문
Risk factors for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP): antecedent events, lifestyle and dietary habits. Data from the Italian CIDP Database.
Document Type
Academic Journal
Author
Doneddu PE; Humanitas Clinical and Research Institute, Milan, Italy.; Bianchi E; Istituto Mario Negri IRCCS, Milan, Italy.; Cocito D; University of Turin, Turin, Italy.; Manganelli F; University of Naples 'Federico II', Naples, Italy.; Fazio R; San Raffaele Scientific Institute, Milan, Italy.; Filosto M; ASST 'Spedali Civili', University of Brescia, Brescia, Italy.; Mazzeo A; University of Messina, Messina, Italy.; Cosentino G; University of Palermo, Palermo, Italy.; Cortese A; IRCCS Foundation C. Mondino National Neurological Institute, Pavia, Italy.; Jann S; Niguarda Ca' Granda Hospital, Milan, Italy.; Clerici AM; Circolo and Macchi Foundation Hospital, Insubria University, DBSV, Varese, Italy.; Antonini G; 'Sapienza' University of Rome, Sant'Andrea Hospital, Rome, Italy.; Siciliano G; University of Pisa, Pisa, Italy.; Luigetti M; Catholic University of Sacred Heart, Rome, Italy.; Marfia GA; Tor Vergata University of Rome, Rome, Italy.; Briani C; University of Padua, Padua, Italy.; Lauria G; IRCCS Foundation 'Carlo Besta' Neurological Institute, University of Milan, Milan, Italy.; Rosso T; UOC Neurologia-Castelfranco Veneto, Treviso, Italy.; Cavaletti G; University of Milano-Bicocca, Monza, Italy.; Carpo M; ASST Bergamo Ovest-Ospedale Treviglio, Treviglio, Italy.; Benedetti L; Sant'Andrea Hospital, La Spezia, Italy.; Beghi E; Istituto Mario Negri IRCCS, Milan, Italy.; Liberatore G; Humanitas Clinical and Research Institute, Milan, Italy.; Santoro L; University of Naples 'Federico II', Naples, Italy.; Peci E; University of Turin, Turin, Italy.; Tronci S; San Raffaele Scientific Institute, Milan, Italy.; Cotti Piccinelli S; ASST 'Spedali Civili', University of Brescia, Brescia, Italy.; Toscano A; University of Messina, Messina, Italy.; Piccolo L; IRCCS Foundation C. Mondino National Neurological Institute, Pavia, Italy.; Verrengia EP; Niguarda Ca' Granda Hospital, Milan, Italy.; Leonardi L; 'Sapienza' University of Rome, Sant'Andrea Hospital, Rome, Italy.; Schirinzi E; University of Pisa, Pisa, Italy.; Mataluni G; Tor Vergata University of Rome, Rome, Italy.; Ruiz M; University of Padua, Padua, Italy.; Dacci P; IRCCS Foundation 'Carlo Besta' Neurological Institute, University of Milan, Milan, Italy.; Nobile-Orazio E; Humanitas Clinical and Research Institute, Milan, Italy.; Milan University, Milan, Italy.
Source
Publisher: Wiley Country of Publication: England NLM ID: 9506311 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-1331 (Electronic) Linking ISSN: 13515101 NLM ISO Abbreviation: Eur J Neurol Subsets: MEDLINE
Subject
Language
English
Abstract
Background and Purpose: The role of lifestyle and dietary habits and antecedent events has not been clearly identified in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP).
Methods: Information was collected about modifiable environmental factors and antecedent infections and vaccinations in patients with CIDP included in an Italian CIDP Database. Only patients who reported not having changed their diet or the lifestyle habits investigated in the study after the appearance of CIDP were included. The partners of patients with CIDP were chosen as controls. Gender-matched analysis was performed with randomly selected controls with a 1:1 ratio of patients and controls.
Results: Dietary and lifestyle data of 323 patients and 266 controls were available. A total of 195 cases and 195 sex-matched controls were used in the analysis. Patients eating rice at least three times per week or eating fish at least once per week appeared to be at decreased risk of acquiring CIDP. Data on antecedent events were collected in 411 patients. Antecedent events within 1-42 days before CIDP onset were reported by 15.5% of the patients, including infections in 12% and vaccinations in 1.5%. Patients with CIDP and antecedent infections more often had an acute onset of CIDP and cranial nerve involvement than those without these antecedent events.
Conclusions: The results of this preliminary study seem to indicate that some dietary habits may influence the risk of CIDP and that antecedent infections may have an impact on the onset and clinical presentation of the disease.
(© European Academy of Neurology 2019.)
Methods: Information was collected about modifiable environmental factors and antecedent infections and vaccinations in patients with CIDP included in an Italian CIDP Database. Only patients who reported not having changed their diet or the lifestyle habits investigated in the study after the appearance of CIDP were included. The partners of patients with CIDP were chosen as controls. Gender-matched analysis was performed with randomly selected controls with a 1:1 ratio of patients and controls.
Results: Dietary and lifestyle data of 323 patients and 266 controls were available. A total of 195 cases and 195 sex-matched controls were used in the analysis. Patients eating rice at least three times per week or eating fish at least once per week appeared to be at decreased risk of acquiring CIDP. Data on antecedent events were collected in 411 patients. Antecedent events within 1-42 days before CIDP onset were reported by 15.5% of the patients, including infections in 12% and vaccinations in 1.5%. Patients with CIDP and antecedent infections more often had an acute onset of CIDP and cranial nerve involvement than those without these antecedent events.
Conclusions: The results of this preliminary study seem to indicate that some dietary habits may influence the risk of CIDP and that antecedent infections may have an impact on the onset and clinical presentation of the disease.
(© European Academy of Neurology 2019.)