학술논문
Characteristics and Clinical Course of Adult in Patients with SARS-CoV-2 Pneumonia at High Altitude.
Document Type
Academic Journal
Author
Galindo JL; Department of Pneumology, Hospital Universitario Mayor Méderi, Bogotá, Colombia.; School of Medicine, Universidad Del Rosario, Bogotá, Colombia.; Lutz JR; Department of Pneumology, Hospital Universitario Mayor Méderi, Bogotá, Colombia.; School of Medicine, Universidad Del Rosario, Bogotá, Colombia.; Izquierdo MA; Department of Pneumology, Hospital Universitario Mayor Méderi, Bogotá, Colombia.; School of Medicine, Universidad Del Rosario, Bogotá, Colombia.; Parra K; Department of Pneumology, Hospital Universitario Mayor Méderi, Bogotá, Colombia.; School of Medicine, Universidad Del Rosario, Bogotá, Colombia.; Prieto LM; Department of Surveillance and Epidemiology, Hospital Universitario Mayor Méderi, Bogotá, Colombia.; Carrillo JA; Department of Pneumology, Hospital Universitario Mayor Méderi, Bogotá, Colombia.; Department of Radiology, Hospital Universitario Mayor Méderi, Bogotá, Colombia.
Source
Publisher: Hindawi Publishing Corporation Country of Publication: Egypt NLM ID: 9433332 Publication Model: eCollection Cited Medium: Internet ISSN: 1916-7245 (Electronic) Linking ISSN: 11982241 NLM ISO Abbreviation: Can Respir J Subsets: MEDLINE
Subject
Language
English
Abstract
Background: SARS-CoV-2 has spread worldwide with different dynamics in each region. We aimed to describe the clinical characteristics and to explore risk factors of death, critical care admission, and use of invasive mechanical ventilation in hospitalized patients with SARS-CoV-2 pneumonia in a high-altitude population living in Bogotá, Colombia.
Methods: We conducted a concurrent cohort study of adult patients with laboratory-confirmed SARS-CoV-2 pneumonia. Demographic, clinical, and treatment data were extracted from electronic records. Univariate and multivariable methods were performed to investigate the relationship between each variable and outcomes at 28 days of follow-up.
Results: 377 adults (56.8% male) were included in the study, of whom 85 (22.6%) died. Nonsurvivors were older on average than survivors (mean age, 56.7 years [SD 15.8] vs. 70.1 years [SD 13.9]; p ≤ 0.001) and more likely male (28 [32.9%] vs. 57 [67.1%]; p =0.029). Most patients had at least one underlying disease (333 [88.3%]), including arterial hypertension (149 [39.5%]), overweight (145 [38.5%]), obesity (114 [30.2%]), and diabetes mellitus (82 [21.8%]). Frequency of critical care admission (158 [41.9%]) and invasive mechanical ventilation (123 [32.6%]) was high. Age over 65 years (OR 9.26, 95% CI 3.29-26.01; p ≤ 0.001), ICU admission (OR 12.37, 95% CI 6.08-25.18; p ≤ 0.001), and arterial pH higher than 7.47 (OR 0.25, 95% CI 0.08-0.74; p =0.01) were independently associated with in-hospital mortality.
Conclusions: In this study of in-hospital patients with SARS-CoV-2 pneumonia living at high altitude, frequency of death was similar to what has been reported. ICU admission and use of invasive mechanical ventilation were high. Risk factors as older age, ICU admission, and arterial pH were associated with mortality.
Competing Interests: The authors declare that they have no conflicts of interest regarding the publication of this article.
(Copyright © 2021 Javier Leonardo Galindo et al.)
Methods: We conducted a concurrent cohort study of adult patients with laboratory-confirmed SARS-CoV-2 pneumonia. Demographic, clinical, and treatment data were extracted from electronic records. Univariate and multivariable methods were performed to investigate the relationship between each variable and outcomes at 28 days of follow-up.
Results: 377 adults (56.8% male) were included in the study, of whom 85 (22.6%) died. Nonsurvivors were older on average than survivors (mean age, 56.7 years [SD 15.8] vs. 70.1 years [SD 13.9]; p ≤ 0.001) and more likely male (28 [32.9%] vs. 57 [67.1%]; p =0.029). Most patients had at least one underlying disease (333 [88.3%]), including arterial hypertension (149 [39.5%]), overweight (145 [38.5%]), obesity (114 [30.2%]), and diabetes mellitus (82 [21.8%]). Frequency of critical care admission (158 [41.9%]) and invasive mechanical ventilation (123 [32.6%]) was high. Age over 65 years (OR 9.26, 95% CI 3.29-26.01; p ≤ 0.001), ICU admission (OR 12.37, 95% CI 6.08-25.18; p ≤ 0.001), and arterial pH higher than 7.47 (OR 0.25, 95% CI 0.08-0.74; p =0.01) were independently associated with in-hospital mortality.
Conclusions: In this study of in-hospital patients with SARS-CoV-2 pneumonia living at high altitude, frequency of death was similar to what has been reported. ICU admission and use of invasive mechanical ventilation were high. Risk factors as older age, ICU admission, and arterial pH were associated with mortality.
Competing Interests: The authors declare that they have no conflicts of interest regarding the publication of this article.
(Copyright © 2021 Javier Leonardo Galindo et al.)