학술논문
Sodium Tungstate (NaW) Decreases Reactive Oxygen Species (ROS) Production in Cells: New Cellular Antioxidant.
Document Type
Academic Journal
Author
Yañez AJ; Facultad de Ciencias, Universidad Austral de Chile, Valdivia 5090000, Chile.; Interdisciplinary Center for Aquaculture Research (INCAR), Universidad de Concepción, Concepción 4030000, Chile.; Jaramillo K; Facultad de Ciencias, Universidad Austral de Chile, Valdivia 5090000, Chile.; Blaña C; Facultad de Ciencias, Universidad Austral de Chile, Valdivia 5090000, Chile.; Burgos RA; Instituto de Farmacología y Morfofisiología, Facultad de Ciencias Veterinarias, UACH Campus Isla Teja, Valdivia 5090000, Chile.; Isla A; Interdisciplinary Center for Aquaculture Research (INCAR), Universidad de Concepción, Concepción 4030000, Chile.; Departamento de Ciencias Básicas, Facultad de Ciencias, Universidad Santo Tomás, Valdivia 5090000, Chile.; Silva P; Facultad de Ciencias, Universidad Austral de Chile, Valdivia 5090000, Chile.; Aguilar M; Facultad de Ciencias, Universidad Austral de Chile, Valdivia 5090000, Chile.
Source
Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101691304 Publication Model: Electronic Cited Medium: Print ISSN: 2227-9059 (Print) Linking ISSN: 22279059 NLM ISO Abbreviation: Biomedicines Subsets: PubMed not MEDLINE
Subject
Language
English
ISSN
2227-9059
Abstract
Diabetic nephropathy (DN) is the leading cause of end-stage renal failure worldwide. Hyperglycemia generates reactive oxygen species (ROS), contributing to diabetic complications, especially in DN. Sodium Tungstate (NaW) is an effective antidiabetic agent for short and long-term treatments of both type 1 and type 2 diabetes models. In this study, we evaluated the effect of NaW on ROS production in bovine neutrophils incubated with platelet-activating factor (PAF) and in HK-2 cells induced by high glucose or H 2 O 2 . In addition, we evaluated the effect on iNOS expression in the type 1 diabetic rat model induced with streptozotocin (STZ). NaW inhibited ROS production in PAF-induced bovine neutrophils, and human tubular cells (HK-2) were incubated in high glucose or H 2 O 2 . In addition, NaW inhibited iNOS expression in glomeruli and tubular cells in the type 1 diabetic rat. This study demonstrates a new role for NaW as an active antioxidant and its potential use in treating DN.