학술논문
Genomic and proteomic aspects of p57 protein from Renibacterium salmoninarum: Characteristics in virulence patterns.
Document Type
Academic Journal
Author
Aguilar M; Laboratorio de Diagnostico y Terapia, Facultad de Ciencias, Universidad Austral de Chile, Valdivia, Chile.; Isla A; Laboratorio de Diagnostico y Terapia, Facultad de Ciencias, Universidad Austral de Chile, Valdivia, Chile; Departamento de Ciencias Básicas, Facultad de Ciencias, Universidad Santo Tomás, Valdivia, Chile; Center for Aquaculture Research (INCAR), Concepción, Chile.; Barrientos CA; Laboratorio de Diagnostico y Terapia, Facultad de Ciencias, Universidad Austral de Chile, Valdivia, Chile.; Flores-Martin SN; Laboratorio de Diagnostico y Terapia, Facultad de Ciencias, Universidad Austral de Chile, Valdivia, Chile.; Blanco JA; Laboratorio de Diagnostico y Terapia, Facultad de Ciencias, Universidad Austral de Chile, Valdivia, Chile.; Enríquez R; Laboratorio de Inmunología y Estrés de Organismos Acuáticos, Instituto de Patología Animal, Facultad de Ciencias Veterinarias, Universidad Austral de Chile, Chile.; Figueroa J; Center for Aquaculture Research (INCAR), Concepción, Chile; Instituto de Bioquímica y Microbiología, Universidad Austral de Chile, Valdivia, Chile.; Yañez AJ; Laboratorio de Diagnostico y Terapia, Facultad de Ciencias, Universidad Austral de Chile, Valdivia, Chile; Center for Aquaculture Research (INCAR), Concepción, Chile. Electronic address: ayanez@uach.cl.
Source
Publisher: Academic Press Country of Publication: England NLM ID: 8606191 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-1208 (Electronic) Linking ISSN: 08824010 NLM ISO Abbreviation: Microb Pathog Subsets: MEDLINE
Subject
Language
English
Abstract
Renibacterium salmoninarum is one of the oldest known fish bacterial pathogens. This Gram-positive bacterium is the causative agent of Bacterial Kidney Disease (BKD), a chronic infection that primarily infects salmonids at low temperatures. Externally, infected fish may show exophthalmos, skin blisters, ulcerations, and hemorrhages at the base of the fins and along the lateral line. Internally, the kidney, heart, spleen, and liver may show signs of inflammation. The best characterized virulence factor of R. salmoninarum is p57, a 57 kDa protein located on the bacterial cell surface and secreted into surrounding fish tissue. The p57 protein in fish is the main mediator in suppressing the immune system, reducing antibody production, and intervening in cytokine activity. In this review, we will discuss aspects such as single nucleotide polymorphisms (SNPs) that modify the DNA sequence, variants in the number of copies of MSA genes, physical-chemical properties of the signal peptides, and the limited iron conditions that can modify p57 expression and increase the virulence of R. salmoninarum.
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Alejandro Yanez reports financial support was provided by Agencia Nacional de Investigacion y Desarrollo (ANID).
(Copyright © 2022 Elsevier Ltd. All rights reserved.)
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Alejandro Yanez reports financial support was provided by Agencia Nacional de Investigacion y Desarrollo (ANID).
(Copyright © 2022 Elsevier Ltd. All rights reserved.)