학술논문
Intravenous administration of oral N-acetylcysteine.
Document Type
Academic Journal
Author
Yip L; Rocky Mountain Poison and Drug Center and Denver Health Medical Center, Department of Surgery, University of Colorado Health Science Center 80220, USA.; Dart RC; Hurlbut KM
Source
Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0355501 Publication Model: Print Cited Medium: Print ISSN: 0090-3493 (Print) Linking ISSN: 00903493 NLM ISO Abbreviation: Crit Care Med Subsets: MEDLINE
Subject
Language
English
ISSN
0090-3493
Abstract
Objective: To report the indications and adverse events associated with administration of the oral N-acetylcysteine preparation by the intravenous route.
Design: Retrospective consecutive case series analysis of 226,720 Toxic Exposure Surveillance System data sheets from a certified regional poison center during the period January 1, 1992 through December 31, 1993.
Setting: A regional poison center certified by the American Association of Poison Control Centers.
Patients: Seventy-six patients treated with the oral N-acetylcysteine solution by the intravenous route.
Interventions: None.
Measurements and Main Results: We report the indications and adverse events associated with the intravenous administration of the oral N-acetylcysteine preparation. Four (4/76, 5.3%) patients developed adverse events attributable to N-acetylcysteine. None of these events involved hemodynamic, cardiovascular, or pulmonary effects. All reactions occurred during infusion of the initial N-acetylcysteine dose. There were three (3/76, 3.9%) deaths overall; however, they were not attributable to the intravenous administration of the oral N-acetylcysteine preparation.
Conclusions: Intravenous administration of the oral N-acetylcysteine preparation appears to have limited adverse effects and offers another mechanism of delivery of the potentially lifesaving N-acetylcysteine when oral administration is not possible.
Design: Retrospective consecutive case series analysis of 226,720 Toxic Exposure Surveillance System data sheets from a certified regional poison center during the period January 1, 1992 through December 31, 1993.
Setting: A regional poison center certified by the American Association of Poison Control Centers.
Patients: Seventy-six patients treated with the oral N-acetylcysteine solution by the intravenous route.
Interventions: None.
Measurements and Main Results: We report the indications and adverse events associated with the intravenous administration of the oral N-acetylcysteine preparation. Four (4/76, 5.3%) patients developed adverse events attributable to N-acetylcysteine. None of these events involved hemodynamic, cardiovascular, or pulmonary effects. All reactions occurred during infusion of the initial N-acetylcysteine dose. There were three (3/76, 3.9%) deaths overall; however, they were not attributable to the intravenous administration of the oral N-acetylcysteine preparation.
Conclusions: Intravenous administration of the oral N-acetylcysteine preparation appears to have limited adverse effects and offers another mechanism of delivery of the potentially lifesaving N-acetylcysteine when oral administration is not possible.