학술논문
Association of thyroid hormones with blood pressure and arterial stiffness in the general population: The Dali study.
Document Type
Academic Journal
Author
Jamal MT; Department of Gerontology, The First Affiliated Hospital of Dali University, Dali, China.; Li QL; Department of Gerontology, The First Affiliated Hospital of Dali University, Dali, China.; Li QY; Department of Gerontology, The First Affiliated Hospital of Dali University, Dali, China.; Liang WY; Department of Gerontology, The First Affiliated Hospital of Dali University, Dali, China.; Wang LH; Department of Gerontology, The First Affiliated Hospital of Dali University, Dali, China.; Wei JH; Department of Gerontology, The First Affiliated Hospital of Dali University, Dali, China.; Liang Q; Department of Gerontology, The First Affiliated Hospital of Dali University, Dali, China.; Hu NQ; Department of Gerontology, The First Affiliated Hospital of Dali University, Dali, China.; Li LH; Department of Gerontology, The First Affiliated Hospital of Dali University, Dali, China.
Source
Publisher: Wiley Periodicals Inc Country of Publication: United States NLM ID: 100888554 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1751-7176 (Electronic) Linking ISSN: 15246175 NLM ISO Abbreviation: J Clin Hypertens (Greenwich) Subsets: MEDLINE
Subject
Language
English
Abstract
Thyroid dysfunction plays a role in blood pressure (BP) regulation. However, the associations between thyroid function and BP and arterial stiffness in the general Chinese population without thyroid disease are unknown. This population-based cross-sectional study aimed to investigate the association between thyroid function and peripheral and central BP and arterial stiffness in Chinese individuals. After excluding those who had thyroid diseases or incomplete clinical measurements, this study included 691 participants. Of the participants, 444 (64.2%) were women and 215 (31.1%) had hypertension. After adjustment for covariates, serum FT3 was significantly associated with a higher pulse rate in both sexes. In men, each 2.72-fold increase in serum FT4 levels was associated with higher peripheral systolic BP (+10.82 mmHg, p = .005) and pulse pressure (+5.71 mmHg, p = .03). Each 2.72-fold increase in serum FT4 levels was associated with higher central systolic BP (+8.03 mmHg, p = .03) and pulse pressure (+3.89 mmHg, p = .05). In women, serum FT4 was only associated with a higher central pulse pressure (+2.96 mmHg, p = .04). After adjustment for covariates, serum FT4 was significantly associated with a faster cfPWV exclusively in men. Our study showed that serum FT4 is associated with higher peripheral and central BP and faster cfPWV in men, whereas serum FT3 is positively associated with a higher pulse rate in both sexes, indicating that the effects of thyroid function on BP and arterial stiffness are more significant in men than in women.
(© 2020 The Authors. The Journal of Clinical Hypertension published by Wiley Periodicals LLC.)
(© 2020 The Authors. The Journal of Clinical Hypertension published by Wiley Periodicals LLC.)