학술논문
Comparing BOLD and VASO-CBV population receptive field estimates in human visual cortex.
Document Type
Academic Journal
Author
Oliveira ÍAF; Spinoza Centre for Neuroimaging, Meibergdreef 75, Amsterdam 1105 BK, the Netherland; Experimental and Applied Psychology, VU University, Amsterdam, the Netherland. Electronic address: i.oliveira@spinozacentre.nl.; Cai Y; Spinoza Centre for Neuroimaging, Meibergdreef 75, Amsterdam 1105 BK, the Netherland; Experimental and Applied Psychology, VU University, Amsterdam, the Netherland.; Hofstetter S; Spinoza Centre for Neuroimaging, Meibergdreef 75, Amsterdam 1105 BK, the Netherland.; Siero JCW; Spinoza Centre for Neuroimaging, Meibergdreef 75, Amsterdam 1105 BK, the Netherland; Radiology, Utrecht Center for Image Sciences, University Medical Center Utrecht, Utrecht, the Netherland.; van der Zwaag W; Spinoza Centre for Neuroimaging, Meibergdreef 75, Amsterdam 1105 BK, the Netherland.; Dumoulin SO; Spinoza Centre for Neuroimaging, Meibergdreef 75, Amsterdam 1105 BK, the Netherland; Experimental and Applied Psychology, VU University, Amsterdam, the Netherland; Experimental Psychology, Helmholtz Institute, Utrecht University, Utrecht, the Netherland.
Source
Publisher: Academic Press Country of Publication: United States NLM ID: 9215515 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9572 (Electronic) Linking ISSN: 10538119 NLM ISO Abbreviation: Neuroimage Subsets: MEDLINE
Subject
Language
English
Abstract
Vascular Space Occupancy (VASO) is an alternative fMRI approach based on changes in Cerebral Blood Volume (CBV). VASO-CBV fMRI can provide higher spatial specificity than the blood oxygenation level-dependent (BOLD) method because the CBV response is thought to be limited to smaller vessels. To investigate how this technique compares to BOLD fMRI for cognitive neuroscience applications, we compared population receptive field (pRF) mapping estimates between BOLD and VASO-CBV. We hypothesized that VASO-CBV would elicit distinct pRF properties compared to BOLD. Specifically, since pRF size estimates also depend on vascular sources, we hypothesized that reduced vascular blurring might yield narrower pRFs for VASO-CBV measurements. We used a VASO sequence with a double readout 3D EPI sequence at 7T to simultaneously measure VASO-CBV and BOLD responses in the visual cortex while participants viewed conventional pRF mapping stimuli. Both VASO-CBV and BOLD images show similar eccentricity and polar angle maps across all participants. Compared to BOLD-based measurements, VASO-CBV yielded lower tSNR and variance explained. The pRF size changed with eccentricity similarly for VASO-CBV and BOLD, and the pRF size estimates were similar for VASO-CBV and BOLD, even when we equate variance explained between VASO-CBV and BOLD. This result suggests that the vascular component of the pRF size is not dominating in either VASO-CBV or BOLD.
(Copyright © 2021. Published by Elsevier Inc.)
(Copyright © 2021. Published by Elsevier Inc.)