학술논문

Understanding risk and causal mechanisms for developing obesity in infants and young children: A National Institutes of Health workshop.
Document Type
Academic Journal
Author
Aagaard KM; Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Baylor College of Medicine, Houston, Texas, USA.; Department of Molecular and Cell Biology, Baylor College of Medicine, Houston, Texas, USA.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA.; Barkin SL; Department of Pediatrics, Children's Hospital of Richmond, Virginia Commonwealth University, Richmond, Virginia, USA.; Burant CF; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.; Carnell S; Division of Child and Adolescent Psychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Demerath E; Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, USA.; Donovan SM; Division of Nutritional Sciences, University of Illinois, Urbana-Champaign, Illinois, USA.; Department of Food Science and Human Nutrition, University of Illinois, Urbana-Champaign, Illinois, USA.; Eneli I; Center for Healthy Weight and Nutrition, Department of Pediatrics, Nationwide Children's Hospital, Columbus, Ohio, USA.; Center of Nutrition, Department of Pediatrics, University of Colorado, Aurora, Colorado, USA.; Francis LA; Department of Biobehavioral Health, The Pennsylvania State University, University Park, Pennsylvania, USA.; Gilbert-Diamond D; Department of Epidemiology, Medicine and Pediatrics, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.; Hivert MF; Division of Chronic Disease Research Across the Lifecourse (CoRAL), Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA.; Diabetes Unit, Massachusetts General Hospital, Boston, Massachusetts, USA.; LeBourgeois MK; Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, USA.; Loos RJF; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark.; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Lumeng JC; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, Michigan, USA.; Miller AL; Department of Health Behavior and Health Education, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.; Okely AD; School of Health and Society, Faculty of Arts, Social Sciences and Humanities, University of Wollongong, Wollongong, New South Wales, Australia.; llawarra Health and Medical Research Institute, Wollongong, New South Wales, Australia.; Department of Sport, Food, and Natural Sciences, Western Norway University of Applied Sciences, Sogndal, Norway.; Osganian SK; National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.; Ramirez AG; Department of Population Health Sciences, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.; Trasande L; Department of Pediatrics, New York University (NYU) School of Medicine, New York, New York, USA.; Department of Environmental Medicine, New York University (NYU) School of Medicine, New York, New York, USA.; Department of Population Health, New York University (NYU) School of Medicine, New York, New York, USA.; Van Horn LV; Department of Preventive Medicine, Northwestern University, Chicago, Illinois, USA.; Wake M; Population Health, Murdoch Children's Research Institute, Parkville, Victoria, Australia.; Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia.; Wright RJ; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Institute for Exposomic Research, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, Kravis Children's Hospital, New York, New York, USA.; Yanovski SZ; National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Source
Publisher: Blackwell Publishing Country of Publication: England NLM ID: 100897395 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1467-789X (Electronic) Linking ISSN: 14677881 NLM ISO Abbreviation: Obes Rev Subsets: MEDLINE
Subject
Language
English
Abstract
Obesity in children remains a major public health problem, with the current prevalence in youth ages 2-19 years estimated to be 19.7%. Despite progress in identifying risk factors, current models do not accurately predict development of obesity in early childhood. There is also substantial individual variability in response to a given intervention that is not well understood. On April 29-30, 2021, the National Institutes of Health convened a virtual workshop on "Understanding Risk and Causal Mechanisms for Developing Obesity in Infants and Young Children." The workshop brought together scientists from diverse disciplines to discuss (1) what is known regarding epidemiology and underlying biological and behavioral mechanisms for rapid weight gain and development of obesity and (2) what new approaches can improve risk prediction and gain novel insights into causes of obesity in early life. Participants identified gaps and opportunities for future research to advance understanding of risk and underlying mechanisms for development of obesity in early life. It was emphasized that future studies will require multi-disciplinary efforts across basic, behavioral, and clinical sciences. An exposome framework is needed to elucidate how behavioral, biological, and environmental risk factors interact. Use of novel statistical methods may provide greater insights into causal mechanisms.
(© 2024 World Obesity Federation.)