학술논문
Repeatability of vibration-controlled transient elastography versus magnetic resonance elastography in patients with cirrhosis: A prospective study.
Document Type
Academic Journal
Author
Siddiqi H; MASLD Research Center, Division of Gastroenterology, University of California at San Diego, La Jolla, California, USA.; Huang DQ; MASLD Research Center, Division of Gastroenterology, University of California at San Diego, La Jolla, California, USA.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Mittal N; MASLD Research Center, Division of Gastroenterology, University of California at San Diego, La Jolla, California, USA.; Nourredin N; MASLD Research Center, Division of Gastroenterology, University of California at San Diego, La Jolla, California, USA.; Bettencourt R; MASLD Research Center, Division of Gastroenterology, University of California at San Diego, La Jolla, California, USA.; Madamba E; MASLD Research Center, Division of Gastroenterology, University of California at San Diego, La Jolla, California, USA.; Amangurbanova M; MASLD Research Center, Division of Gastroenterology, University of California at San Diego, La Jolla, California, USA.; Hernandez C; MASLD Research Center, Division of Gastroenterology, University of California at San Diego, La Jolla, California, USA.; Sirlin C; Liver Imaging Group, University of California at San Diego, La Jolla, California, USA.; Yin M; Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.; Loomba R; MASLD Research Center, Division of Gastroenterology, University of California at San Diego, La Jolla, California, USA.; Division of Gastroenterology and Hepatology, University of California at San Diego, La Jolla, California, USA.
Source
Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 8707234 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2036 (Electronic) Linking ISSN: 02692813 NLM ISO Abbreviation: Aliment Pharmacol Ther Subsets: MEDLINE
Subject
Language
English
Abstract
Background and Aims: Magnetic resonance elastography (MRE) and vibration-controlled transient elastography (VCTE) have the potential to assess disease progression; however, repeatability data in people with cirrhosis are lacking. We aimed to assess the effect of disease severity on measurement variability and contribute to the evidentiary basis for the qualification of repeating liver stiffness measurements (LSM) in practice and research.
Methods: This prospective study included 49 adult participants (58.3% female) with cirrhosis who underwent same-day repeat LSM examinations. The primary outcome was the same-day, same-operator repeatability coefficient% (RC%) and the within-case coefficient of variation (wCV) for each modality. Secondary outcomes include the intra-class correlation coefficient (ICC). The relationship between measurement variability (interquartile for VCTE, standard deviation for MRE) and disease severity (mean liver stiffness) was evaluated by linear regression with the coefficient of determination R2 reported.
Results: Same-day repeat MRE and VCTE exams were prospectively conducted in 33 and 45 participants, respectively. The RC% appeared 82% higher for VCTE versus MRE (38% vs. 21%), with consistent findings in head-to-head analyses. The wCV for VCTE and MRE was 14% and 8% respectively, indicating VCTE has 75% higher within-subject measurement variation than MRE. ICC was excellent for LSM by VCTE (0.92) and MRE (0.96). Measurement variability increased with mean liver stiffness for VCTE (R2 = 0.78) and MRE (R 2 = 0.93).
Conclusion: Both VCTE and MRE demonstrated increased measurement variability with disease severity. However, MRE outperformed VCTE in terms of technical repeatability in patients with cirrhosis. These repeatability estimates may improve the qualification of NITs in practice.
(© 2024 John Wiley & Sons Ltd.)
Methods: This prospective study included 49 adult participants (58.3% female) with cirrhosis who underwent same-day repeat LSM examinations. The primary outcome was the same-day, same-operator repeatability coefficient% (RC%) and the within-case coefficient of variation (wCV) for each modality. Secondary outcomes include the intra-class correlation coefficient (ICC). The relationship between measurement variability (interquartile for VCTE, standard deviation for MRE) and disease severity (mean liver stiffness) was evaluated by linear regression with the coefficient of determination R
Results: Same-day repeat MRE and VCTE exams were prospectively conducted in 33 and 45 participants, respectively. The RC% appeared 82% higher for VCTE versus MRE (38% vs. 21%), with consistent findings in head-to-head analyses. The wCV for VCTE and MRE was 14% and 8% respectively, indicating VCTE has 75% higher within-subject measurement variation than MRE. ICC was excellent for LSM by VCTE (0.92) and MRE (0.96). Measurement variability increased with mean liver stiffness for VCTE (R
Conclusion: Both VCTE and MRE demonstrated increased measurement variability with disease severity. However, MRE outperformed VCTE in terms of technical repeatability in patients with cirrhosis. These repeatability estimates may improve the qualification of NITs in practice.
(© 2024 John Wiley & Sons Ltd.)