학술논문
[Molecular epidemiological study on rubella virus circulating in Yunnan Province during 2011-2021].
Document Type
Academic Journal
Author
Li LQ; Expanded Program on Immunization Department, Yunnan Center for Disease Control and Prevention, Kunming 650022, China.; Li JR; Expanded Program on Immunization Department, Yunnan Center for Disease Control and Prevention, Kunming 650022, China.; Yu W; Expanded Program on Immunization Department, Yunnan Center for Disease Control and Prevention, Kunming 650022, China.; Zhang J; Expanded Program on Immunization Department, Yunnan Center for Disease Control and Prevention, Kunming 650022, China.; He LF; Expanded Program on Immunization Department, Yunnan Center for Disease Control and Prevention, Kunming 650022, China.; Gong QY; Expanded Program on Immunization Department, Yunnan Center for Disease Control and Prevention, Kunming 650022, China.; Zhou RR; Expanded Program on Immunization Department, Yunnan Center for Disease Control and Prevention, Kunming 650022, China.; Zhu Z; NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, China Center for Disease Control and Prevention, Beijing 102206, China.
Source
Publisher: Zhonghua yi xue hui Country of Publication: China NLM ID: 7904962 Publication Model: Print Cited Medium: Print ISSN: 0253-9624 (Print) Linking ISSN: 02539624 NLM ISO Abbreviation: Zhonghua Yu Fang Yi Xue Za Zhi Subsets: MEDLINE
Subject
Language
Chinese
ISSN
0253-9624
Abstract
Objective: To understand the genotype distribution and transmission pattern of rubella virus (RuV) circulating in Yunnan Province. Methods: Throat swab samples were collected from rubella outbreaks and sporadic cases in nine prefectures/cities of Yunnan Province from 2011 to 2021. Virus isolation, amplification of target genes and sequence determination were performed on the RuV-positive samples. The genotypes and lineages of Yunnan strains were determined by comparing them with the reference strains, and further phylogenetic analysis was performed with Yunnan strains and strains circulating in other provinces of China during the same period. Results: RuV circulating in Yunnan province during 2011-2021 showed significant genetic diversity, and three lineages, 1E-L1, 2B-L1 and 1E-L2, were detected. Two lineage-switches were also identified, including the conversion of 1E-L1 to 2B-L1 between 2012 and 2013, and the replacement of 2B-L1 to 1E-L2 after 2018. The time of the switches was basically consistent with the outbreak in Yunnan province in 2012 and the time of the rubella reemergence and epidemic between 2018 and 2019. The amino acid sequence of RuV virus strains in Yunnan province was highly conserved, and no important functional regions were changed. Conclusions: The transmission pattern of RuV in Yunnan province is generally consistent with the epidemic trend of RuV in other provinces of China.