학술논문
Zn doped CaP coatings used for controlling the degradation rate of MgCa1 alloy: In vitro anticorrosive properties, sterilization and bacteria/cell-material interactions.
Document Type
Academic Journal
Author
Schmidt J; INNOVENT e.V. Technology Development, Group-Leader Electrochemistry Ilmstraße 18, 07743 Jena, Germany.; Pana I; National Institute of Research and Development for Optoelectronics, INOE 2000, 409 Atomistilor St., 077125 Magurele, Romania.; Bystrova A; Riga Technical University, Institute of Biomedical Engineering and Nanotechnologies, Ķīpsalas str 6B, floor 3, Riga, LV - 1048, Latvia.; Dinu M; National Institute of Research and Development for Optoelectronics, INOE 2000, 409 Atomistilor St., 077125 Magurele, Romania.; Dekhtyar Y; Riga Technical University, Institute of Biomedical Engineering and Nanotechnologies, Ķīpsalas str 6B, floor 3, Riga, LV - 1048, Latvia.; Vitelaru C; National Institute of Research and Development for Optoelectronics, INOE 2000, 409 Atomistilor St., 077125 Magurele, Romania.; Gorohovs M; Riga Technical University, Institute of Biomedical Engineering and Nanotechnologies, Ķīpsalas str 6B, floor 3, Riga, LV - 1048, Latvia.; Marinescu IM; National Institute of Research and Development for Optoelectronics, INOE 2000, 409 Atomistilor St., 077125 Magurele, Romania.; Huri PY; Ankara University, Department of Biomedical Engineering, 06830 Ankara, Turkey.; Tamay DG; Middle East Technical University (METU), Department of Biotechnology, 06800 Ankara, Turkey; METU BIOMATEN, Biomaterials and Tissue Engineering Center of Excellence, 06800 Ankara, Turkey.; Juravlea GA; National Institute of Research and Development for Optoelectronics, INOE 2000, 409 Atomistilor St., 077125 Magurele, Romania.; Buyuksungur S; METU BIOMATEN, Biomaterials and Tissue Engineering Center of Excellence, 06800 Ankara, Turkey.; Parau AC; National Institute of Research and Development for Optoelectronics, INOE 2000, 409 Atomistilor St., 077125 Magurele, Romania.; Hasirci V; Middle East Technical University (METU), Department of Biotechnology, 06800 Ankara, Turkey; METU BIOMATEN, Biomaterials and Tissue Engineering Center of Excellence, 06800 Ankara, Turkey; Biomedical Engineering, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey; Biomaterials Center, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey.; Hasirci N; Middle East Technical University (METU), Department of Biotechnology, 06800 Ankara, Turkey; Biomaterials Center, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey; Middle East Technical University, Department of Chemistry, 06800 Ankara, Turkey; Near East University, Tissue Engineering and Biomaterials Research Center, Nicosia, TRNC, Mersin 10, Turkey. Electronic address: nesrin.hasirci@neu.edu.tr.; Vladescu A; National Institute of Research and Development for Optoelectronics, INOE 2000, 409 Atomistilor St., 077125 Magurele, Romania; Research Center for Physical Materials Science and Composite Materials, National Research Tomsk Polytechnic University, Lenin Avenue 43, Tomsk, 634050, Russia. Electronic address: alinava@inoe.ro.
Source
Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9315133 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4367 (Electronic) Linking ISSN: 09277765 NLM ISO Abbreviation: Colloids Surf B Biointerfaces Subsets: MEDLINE
Subject
Language
English
Abstract
The purpose of this study was to investigate the effect of Zn doped CaP coatings prepared by micro-arc oxidation method, as a possible approach to control MgCa1 alloy degradation. All the prepared coatings comprised a calcium deficient CaP phase. The control in this evaluation was performed with undoped CaP coating in SBF solution at body temperature (37 ± 0.5⁰C). The investigation involved determination of microchemical, mechanical, morphological, properties along with anticorrosive, cytocompatibility and antibacterial efficacy. The effect of sterilization process on the properties of the surfaces was also investigated. The results showed that the addition of Zn into CaP increased the corrosion resistance of MgCa1 alloy. Moreover, the adhesion strength of the coatings to MgCa1 alloy was enhanced by Zn addition. In cytotoxicity testing of the samples, extracts of the samples in MEM were incubated with L929 cells and malformation, degeneration and lysis of the cells were examined microscopically after 72 h. The results showed that all samples were cytocompatible. The degradation of MgCa1 alloy in the simulated body fluids (SBF) or DMEM was decreased by coating with CaP. Moreover, the degradation rate of CaP was further decreased by adding a small amount of Zn into the CaP matrix. The samples having CaP coatings and Zn doped CaP coating demonstrated antibacterial efficacy against E.coli. As a result, coating of magnesium alloy with Zn-doped CaP decreased the degradation rate, increased the corrosion resistance, cytocompatibility and the antibacterial effects of the alloys.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2022 Elsevier B.V. All rights reserved.)
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2022 Elsevier B.V. All rights reserved.)