학술논문
Possible correlation between serum interleukin-8 levels and the activity of myositis in anti-NXP2 antibody-positive dermatomyositis.
Document Type
Academic Journal
Author
Konishi R; Department of Dermatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.; Department of Dermatology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.; Ichimura Y; Department of Dermatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.; Division of Rheumatology, Department of Internal Medicine, Tokyo Women's Medical University School of Medicine, Tokyo, Japan.; Tanaka R; Department of Dermatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.; Department of Dermatology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.; Miyahara H; Department of Dermatology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.; Okune M; Department of Dermatology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.; Miyamoto M; Department of Pediatrics, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.; Hara M; Department of Pediatrics, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.; Iwabuchi A; Department of Pediatrics, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.; Takada H; Department of Pediatrics, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.; Nakagishi Y; Department of Pediatric Rheumatology, Hyogo Prefectural Kobe Children's Hospital, Hyogo, Japan.; Mizuta M; Department of Pediatric Rheumatology, Hyogo Prefectural Kobe Children's Hospital, Hyogo, Japan.; Kaneko S; Department of Pediatrics and Developmental Biology, Faculty of Medicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.; Shimizu M; Department of Pediatrics and Developmental Biology, Faculty of Medicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.; Morio T; Department of Pediatrics and Developmental Biology, Faculty of Medicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.; Nishino I; Department of Neuromuscular Research, National Institute of Neuroscience.; Medical Genome Center, National Center of Neurology and Psychiatry, Tokyo, Japan.; Nomura T; Department of Dermatology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.; Okiyama N; Department of Dermatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.
Source
Publisher: Informa UK Limited Country of Publication: England NLM ID: 101736847 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2578-5826 (Electronic) Linking ISSN: 25785826 NLM ISO Abbreviation: Immunol Med Subsets: MEDLINE
Subject
Language
English
Abstract
Anti-nuclear matrix protein 2 (NXP2) antibody-positive dermatomyositis (DM) is characterized by extensive and severe myositis. In this study, we evaluated which cytokines/chemokines involved with the activity of the myositis. We performed quantitative immunoassays using the MILLIPLEX ® Multiplex Assays Using Luminex to evaluate serum levels of interferon-γ, interleukin (IL)-1β, IL-6, IL-8, IL-12p40, and tumor necrosis factor-α in samples collected over time from a 9-year-old female with anti-NXP2 antibody-positive DM. In our case, the serum level of IL-8 was elevated when the myositis worsened, and decreased in accordance with the improvement of myositis, suggesting that the serum IL-8 levels were correlated with the myositis activity. Serum levels of IL-8 in samples from five patients with anti-NXP2 antibody-positive DM and five patients with anti-transcriptional intermediary factor 1γ (TIF1γ) antibody-positive DM without both interstitial lung disease (ILD) and malignancy before starting treatments, along with five healthy controls, were also evaluate by an enzyme-linked immunosorbent assay. Serum IL-8 levels were significantly elevated in anti-NXP2 or anti-TIF1γ antibody-positive DM patients with myositis but not ILD, than healthy controls. It was suggested that serum levels of IL-8 correlate with the activity of myositis in DM including anti-NXP2 antibody-positive DM.