학술논문
Temporal associations of plasma levels of the secreted phospholipase A 2 family and mortality in severe COVID-19.
Document Type
Academic Journal
Author
Lu E; Department of Molecular and Cellular Biology, University of Arizona, Tucson, Arizona, USA.; Hara A; School of Nutritional Sciences and Wellness, College of Agriculture and Life Sciences, University of Arizona, Tucson, Arizona, USA.; Sun S; Department of Mathematics, University of Arizona, Tucson, Arizona, USA.; Statistics Interdisciplinary Program, University of Arizona, Tucson, Arizona, USA.; Hallmark B; BIO5 Institute, University of Arizona, Tucson, Arizona, USA.; Snider JM; School of Nutritional Sciences and Wellness, College of Agriculture and Life Sciences, University of Arizona, Tucson, Arizona, USA.; Arizona Cancer Center, University of Arizona, Tucson, Arizona, USA.; Center for Precision Nutrition and Wellness, University of Arizona, Tucson, Arizona, USA.; Seeds MC; Wake Forest Institute of Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.; Watkins JC; Department of Mathematics, University of Arizona, Tucson, Arizona, USA.; Statistics Interdisciplinary Program, University of Arizona, Tucson, Arizona, USA.; McCall CE; Departments of Internal Medicine, Microbiology and Immunology, and Clinical and Translational Sciences Institute, Wake Forest School of Medicine, Winston Salem, North Carolina, USA.; Zhang HH; Department of Mathematics, University of Arizona, Tucson, Arizona, USA.; Statistics Interdisciplinary Program, University of Arizona, Tucson, Arizona, USA.; Yao G; Department of Molecular and Cellular Biology, University of Arizona, Tucson, Arizona, USA.; Chilton FH; School of Nutritional Sciences and Wellness, College of Agriculture and Life Sciences, University of Arizona, Tucson, Arizona, USA.; BIO5 Institute, University of Arizona, Tucson, Arizona, USA.; Center for Precision Nutrition and Wellness, University of Arizona, Tucson, Arizona, USA.
Source
Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 1273201 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-4141 (Electronic) Linking ISSN: 00142980 NLM ISO Abbreviation: Eur J Immunol Subsets: MEDLINE
Subject
Language
English
Abstract
Previous research suggests that group IIA-secreted phospholipase A 2 (sPLA 2 -IIA) plays a role in and predicts lethal COVID-19 disease. The current study reanalyzed a longitudinal proteomic data set to determine the temporal relationship between levels of several members of a family of sPLA 2 isoforms and the severity of COVID-19 in 214 ICU patients. The levels of six secreted PLA 2 isoforms, sPLA 2 -IIA, sPLA 2 -V, sPLA 2 -X, sPLA 2 -IB, sPLA 2 -IIC, and sPLA 2 -XVI, increased over the first 7 ICU days in those who succumbed to the disease but attenuated over the same time period in survivors. In contrast, a reversed pattern in sPLA 2 -IID and sPLA 2 -XIIB levels over 7 days suggests a protective role of these two isoforms. Furthermore, decision tree models demonstrated that sPLA 2 -IIA outperformed top-ranked cytokines and chemokines as a predictor of patient outcome. Taken together, proteomic analysis revealed temporal sPLA 2 patterns that reflect the critical roles of sPLA 2 isoforms in severe COVID-19 disease.
(© 2024 The Authors. European Journal of Immunology published by Wiley‐VCH GmbH.)
(© 2024 The Authors. European Journal of Immunology published by Wiley‐VCH GmbH.)