학술논문
Significance of Persistent Systemic Support in the Clinical Course of Delayed Post-hypoxic Leukoencephalopathy Following Severe Coronavirus Disease 2019.
Document Type
Academic Journal
Author
Kawasaki J; Division of Pulmonary Medicine, Department of Medicine, Jichi Medical University, Japan.; Mato N; Division of Pulmonary Medicine, Department of Medicine, Jichi Medical University, Japan.; Fujii H; Department of Radiology, Jichi Medical University, Japan.; Miura K; Division of Neurology, Department of Medicine, Jichi Medical University, Japan.; Mashiko T; Division of Neurology, Department of Medicine, Jichi Medical University, Japan.; Katayama S; Division of Intensive Care, Department of Anesthesiology and Intensive Care Medicine, Jichi Medical University, Japan.; Yamanouchi Y; Division of Pulmonary Medicine, Department of Medicine, Jichi Medical University, Japan.; Sato M; Postgraduate Clinical Training Center, Jichi Medical University Hospital, Japan.; Takasaki T; Division of Pulmonary Medicine, Department of Medicine, Jichi Medical University, Japan.; Takigami A; Division of Pulmonary Medicine, Department of Medicine, Jichi Medical University, Japan.; Hisata S; Division of Pulmonary Medicine, Department of Medicine, Jichi Medical University, Japan.; Nunomiya S; Division of Intensive Care, Department of Anesthesiology and Intensive Care Medicine, Jichi Medical University, Japan.; Hagiwara K; Division of Pulmonary Medicine, Department of Medicine, Jichi Medical University, Japan.; Maemondo M; Division of Pulmonary Medicine, Department of Medicine, Jichi Medical University, Japan.
Source
Publisher: Japanese Society of Internal Medicine Country of Publication: Japan NLM ID: 9204241 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1349-7235 (Electronic) Linking ISSN: 09182918 NLM ISO Abbreviation: Intern Med Subsets: MEDLINE
Subject
Language
English
Abstract
A 45-year-old woman was hospitalized with severe coronavirus disease 2019 pneumonia. Following cytokine storm-induced multiorgan failure and lethal arrhythmia, the patient developed a sustained coma with flaccid quadriplegia. A cerebrospinal fluid examination excluded infectious and immunogenic encephalopathies, and diffusion-weighted magnetic resonance imaging demonstrated high-intensity areas in the white matter with a cortex-sparing distribution, suggesting delayed post-hypoxic leukoencephalopathy. As a result of intensive cardiopulmonary support for a month, the neurological function gradually recovered. Based on the reversible clinical course noted in this patient, accurate diagnosis and persistent medical approaches are important for the management of coronavirus disease 2019-related delayed post-hypoxic leukoencephalopathy.