학술논문
Nanoscale Treatment of Intervertebral Disc Degeneration: Mesenchymal Stem Cell Exosome Transplantation.
Document Type
Academic Journal
Author
Hu YC; Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou, Gansu 730000, PR China.; Key Laboratory of Bone and Joint Disease Research of Gansu Province, Lanzhou, Gansu 730000, PR China.; Zhang XB; Department of Orthopedics, Honghui Hospital, Xi'an, Shanxi, 710000, PR China.; Lin MQ; Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou, Gansu 730000, PR China.; Key Laboratory of Bone and Joint Disease Research of Gansu Province, Lanzhou, Gansu 730000, PR China.; Zhou HY; Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou, Gansu 730000, PR China.; Key Laboratory of Bone and Joint Disease Research of Gansu Province, Lanzhou, Gansu 730000, PR China.; Cong MX; Department of Oncology, Yanbian University Hospital, Yanji, Jilin, 133000, PR China.; Chen XY; Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou, Gansu 730000, PR China.; Key Laboratory of Bone and Joint Disease Research of Gansu Province, Lanzhou, Gansu 730000, PR China.; Zhang RH; Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou, Gansu 730000, PR China.; Key Laboratory of Bone and Joint Disease Research of Gansu Province, Lanzhou, Gansu 730000, PR China.; Yu DC; Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou, Gansu 730000, PR China.; Key Laboratory of Bone and Joint Disease Research of Gansu Province, Lanzhou, Gansu 730000, PR China.; Gao XD; Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou, Gansu 730000, PR China.; Key Laboratory of Bone and Joint Disease Research of Gansu Province, Lanzhou, Gansu 730000, PR China.; Guo TW; Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou, Gansu 730000, PR China.; Key Laboratory of Bone and Joint Disease Research of Gansu Province, Lanzhou, Gansu 730000, PR China.
Source
Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 101272517 Publication Model: Print Cited Medium: Internet ISSN: 2212-3946 (Electronic) Linking ISSN: 1574888X NLM ISO Abbreviation: Curr Stem Cell Res Ther Subsets: MEDLINE
Subject
Language
English
Abstract
A common surgical disease, intervertebral disc degeneration (IVDD), is increasing at an alarming rate in younger individuals. Repairing damaged intervertebral discs (IVDs) and promoting IVD tissue regeneration at the molecular level are important research goals.Exosomes are extracellular vesicles (EVs) secreted by cells and can be derived from most body fluids. Mesenchymal stem cell-derived exosomes (MSC-exos) have characteristics similar to those of the parental MSCs. These EVs can shuttle various macromolecular substances, such as proteins, messenger RNAs (mRNAs), and microRNAs (miRNAs) and regulate the activity of recipient cells through intercellular communication. Reducing inflammation and apoptosis can significantly promote IVD regeneration to facilitate the repair of the IVD. Compared with MSCs, exosomes are more convenient to store and transport, and the use of exosomes can prevent the risk of rejection with cell transplantation. Furthermore, MSC-exo-mediated treatment may be safer and more effective than MSC transplantation. In this review, we summarize the use of bone marrow mesenchymal stem cells (BMSCs), adipose-derived mesenchymal stem cells (AMSCs), nucleus pulposus mesenchymal stem cells (NPMSCs), and stem cells from other sources for tissue engineering and use in IVDD. Here, we aim to describe the role of exosomes in inhibiting IVDD, their potential therapeutic effects, the results of the most recent research, and their clinical application prospects to provide an overview for researchers seeking to explore new treatment strategies and improve the efficacy of IVDD treatment.
(Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
(Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)