학술논문
Natural History Analysis of 101 Severe Dysplasia and Esophageal Carcinoma Cases by Endoscopy.
Document Type
Academic Journal
Author
Wang JW; Department of Pathology, Cancer Hospital of Linzhou, Henan, China.; Guan CT; Department of Cancer Epidemiology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.; Wang LL; Department of Epidemiology, Cancer Hospital of Linzhou, Henan, China.; Chang LY; Department of Pathology, Cancer Hospital of Linzhou, Henan, China.; Hao CQ; Department of Endoscopy, Cancer Hospital of Linzhou, Henan, China.; Li BY; Department of Epidemiology, Cancer Hospital of Linzhou, Henan, China.; Lu N; Department of Pathology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.; Wei WQ; Department of Cancer Epidemiology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
Source
Publisher: Hindawi Publishing Corporation Country of Publication: Egypt NLM ID: 101475557 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1687-6121 (Print) Linking ISSN: 16876121 NLM ISO Abbreviation: Gastroenterol Res Pract Subsets: PubMed not MEDLINE
Subject
Language
English
ISSN
1687-6121
Abstract
Objectives . Our research is to realize the natural history from dysplasia to carcinoma and to provide evidence for exploring proper screening intervals. Methods . After the onset endoscopy screening, 2093 of the patients participated in the endoscopic follow-up voluntarily. Totally, 101 severe dysplasia and carcinoma cases, either diagnosed in the first endoscopy without treatment or diagnosed in the second endoscopy, were included in our study. We compared the pathologic results of their two endoscopies and calculate the mean and median progression time. Results . Of the 39 severe dysplasia cases diagnosed by the onset endoscopy, only 8 progressed to carcinoma. For severe dysplasia cases diagnosed by the follow-up endoscopy, mean progression times are 55.0, 49.8, and 38.0 months and median progression times are 43, 56, and 31 months for esophagitis, mild dysplasia, and moderate dysplasia, respectively. For superficial carcinoma cases diagnosed by the second endoscopy, mean progression times are 76.0, 57.4, and 47.0 months and median progression times are 77, 63, and 35 months for mild dysplasia, moderate dysplasia, and severe dysplasia, respectively. Conclusions . Population-based severe dysplasia cases may have much lower carcinoma progression rate than specific-selected ones. The progression time for most enrolled cases seems longer than that of the recent screening protocol recommended.