학술논문
Associations of dietary sugars with liver stiffness in Latino adolescents with obesity differ on PNPLA3 and liver disease severity.
Document Type
Academic Journal
Author
Schenker RB; Department of Pediatric Gastroenterology, Hepatology, and Nutrition, Children's Hospital Los Angeles, Los Angeles, California, USA.; Machle CJ; Department of Pediatrics, Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, California, USA.; Department of Psychology, University of Oregon, Eugene, Oregon, USA.; Schmidt KA; Department of Pediatrics, Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, California, USA.; Allayee H; Departments of Population & Public Health Sciences and Biochemistry & Molecular Medicine, University of Southern California, Los Angeles, California, USA.; Kohli R; Department of Pediatric Gastroenterology, Hepatology, and Nutrition, Children's Hospital Los Angeles, Los Angeles, California, USA.; Goran MI; Department of Pediatrics, Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, California, USA.
Source
Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 101160857 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-3231 (Electronic) Linking ISSN: 14783223 NLM ISO Abbreviation: Liver Int Subsets: MEDLINE
Subject
Language
English
Abstract
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common paediatric liver disease. Latinos have high MASLD risk due to 50% prevalence of GG genotype of PNPLA3. Our primary aim was to evaluate associations between dietary carbohydrates/sugars and liver stiffness in Latino adolescents with obesity. Our secondary aim was to examine effect modification by (a) PNPLA3 genotype or (b) liver disease severity. Data were obtained from 114 Latino adolescents with obesity involved in two prior studies. No associations were seen between dietary carbohydrates/sugars and liver stiffness in the group as a whole. In subjects with GG genotype of PNPLA3, total sugar, fructose, sucrose, and glucose were associated with liver stiffness. Positive relationships between carbohydrate, total sugar, and sucrose and liver stiffness were stronger in those with MASLD and fibrosis compared to those with healthy livers and MASLD without fibrosis.
(© 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
(© 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)