학술논문
Air pollution exposure may impact the composition of human milk oligosaccharides.
Document Type
Academic Journal
Author
Naik NC; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.; Cleveland Clinic Lerner College of Medicine at Case Western Reserve University College of Medicine, Cleveland, OH, USA.; Holzhausen EA; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.; Chalifour BN; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.; Coffman MM; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.; Lurmann F; Sonoma Technology, Inc., Petaluma, CA, USA.; Goran MI; Department of Pediatrics, Children's Hospital of Los Angeles, Los Angeles, CA, USA.; Bode L; Department of Pediatrics, Larson-Rosenquist Foundation Mother-Milk-Infant Center of Research Excellence (MOMI CORE), Human Milk Institute (HMI), University of California, San Diego, La Jolla, CA, USA.; Alderete TL; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA. tanya.alderete@colorado.edu.
Source
Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Subject
Language
English
Abstract
Human milk oligosaccharides (HMOs) impact neonate immunity and health outcomes. However, the environmental factors influencing HMO composition remain understudied. This study examined the associations between ambient air pollutant (AAP) exposure and HMOs at 1-month postpartum. Human milk samples were collected at 1-month postpartum (n = 185). AAP (PM 2.5 , PM 10 , NO 2 ) exposure included the 9-month pregnancy period through 1-month postpartum. Associations between AAP with (1) HMO diversity, (2) the sum of sialylated and fucosylated HMOs, (3) 6 a priori HMOs linked with infant health, and (4) all HMOs were examined using multivariable linear regression and principal component analysis (PCA). Exposure to AAP was associated with lower HMO diversity. PM 2.5 and PM 10 exposure was positively associated with the HMO 3-fucosyllactose (3FL); PM 2.5 exposure was positively associated with the sum of total HMOs, sum of fucosylated HMOs, and the HMO 2'-fucosyllactose (2'FL). PCA indicated the PM 2.5 , PM 10 , and NO 2 exposures were associated with HMO profiles. Individual models indicated that AAP exposure was associated with five additional HMOs (LNFP I, LNFP II, DFLNT, LNH). This is the first study to demonstrate associations between AAP and breast milk HMOs. Future longitudinal studies will help determine the long-term impact of AAP on human milk composition.
(© 2024. The Author(s).)
(© 2024. The Author(s).)