학술논문
Examining potential Long COVID effects through utilization of healthcare resources: a retrospective, population-based, matched cohort study comparing individuals with and without prior SARS-CoV-2 infection.
Document Type
Academic Journal
Author
Castriotta L; Institute of Hygiene and Evaluative Epidemiology, Friuli Centrale University Health Authority, Udine, Italy.; Central Directorate for Health, Social Policies and Disability, Friuli Venezia Giulia Region, Trieste, Italy.; Onder G; Istituto Superiore di Sanità-Italian National Institute of Health, Rome, Italy.; Fondazione Policlinico Gemelli IRCCS, Rome, Italy.; Università Cattolica del Sacro Cuore, Rome, Italy.; Rosolen V; Central Directorate for Health, Social Policies and Disability, Friuli Venezia Giulia Region, Trieste, Italy.; Beorchia Y; Institute of Hygiene and Evaluative Epidemiology, Friuli Centrale University Health Authority, Udine, Italy.; Fanizza C; Agenzia Regionale Strategica per la Salute e il Sociale, Regione Puglia, Bari, Italy.; Bellini B; Agenzia Regionale di Sanità, Regione Toscana, Firenze, Italy.; Agenzia Italiana del Farmaco-Italian Medicines Agency, Rome, Italy.; Floridia M; Istituto Superiore di Sanità-Italian National Institute of Health, Rome, Italy.; Giuliano M; Istituto Superiore di Sanità-Italian National Institute of Health, Rome, Italy.; Silenzi A; Italian Ministry of Health, Rome, Italy.; Pricci F; Istituto Superiore di Sanità-Italian National Institute of Health, Rome, Italy.; Grisetti T; Istituto Superiore di Sanità-Italian National Institute of Health, Rome, Italy.; Grassi T; Istituto Superiore di Sanità-Italian National Institute of Health, Rome, Italy.; Tiple D; Istituto Superiore di Sanità-Italian National Institute of Health, Rome, Italy.; Villa M; Istituto Superiore di Sanità-Italian National Institute of Health, Rome, Italy.; Profili F; Agenzia Regionale di Sanità, Regione Toscana, Firenze, Italy.; Francesconi P; Agenzia Regionale di Sanità, Regione Toscana, Firenze, Italy.; Barbone F; Central Directorate for Health, Social Policies and Disability, Friuli Venezia Giulia Region, Trieste, Italy.; Dipartimento Universitario Clinico di Scienze Mediche Chirurgiche e della Salute, Università degli Studi di Trieste, Trieste, Italy.; Bisceglia L; Agenzia Regionale Strategica per la Salute e il Sociale, Regione Puglia, Bari, Italy.; Brusaferro S; Istituto Superiore di Sanità-Italian National Institute of Health, Rome, Italy.
Source
Publisher: Oxford University Press Country of Publication: England NLM ID: 9204966 Publication Model: Print Cited Medium: Internet ISSN: 1464-360X (Electronic) Linking ISSN: 11011262 NLM ISO Abbreviation: Eur J Public Health Subsets: MEDLINE
Subject
Language
English
Abstract
Background: A significant proportion of individuals reports persistent clinical manifestations following SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) acute infection. Nevertheless, knowledge of the burden of this condition-often referred to as 'Long COVID'-on the health care system remains limited. This study aimed to evaluate healthcare utilization potentially related to Long COVID.
Methods: Population-based, retrospective, multi-center cohort study that analyzed hospital admissions and utilization of outpatient visits and diagnostic tests between adults aged 40 years and older recovered from SARS-CoV-2 infection occurred between February 2020 and December 2021 and matched unexposed individuals during a 6-month observation period. Healthcare utilization was analyzed by considering the setting of care for acute SARS-CoV-2 infection [non-hospitalized, hospitalized and intensive care unit (ICU)-admitted] as a proxy for the severity of acute infection and epidemic phases characterized by different SARS-CoV-2 variants. Data were retrieved from regional health administrative databases of three Italian Regions.
Results: The final cohort consisted of 307 994 previously SARS-CoV-2 infected matched with 307 994 uninfected individuals. Among exposed individuals, 92.2% were not hospitalized during the acute infection, 7.3% were hospitalized in a non-ICU ward and 0.5% were admitted to ICU. Individuals previously infected with SARS-CoV-2 (vs. unexposed), especially those hospitalized or admitted to ICU, reported higher utilization of outpatient visits (range of pooled Incidence Rate Ratios across phases; non-hospitalized: 1.11-1.33, hospitalized: 1.93-2.19, ICU-admitted: 3.01-3.40), diagnostic tests (non-hospitalized: 1.35-1.84, hospitalized: 2.86-3.43, ICU-admitted: 4.72-7.03) and hospitalizations (non-hospitalized: 1.00-1.52, hospitalized: 1.87-2.36, ICU-admitted: 4.69-5.38).
Conclusions: This study found that SARS-CoV-2 infection was associated with increased use of health care in the 6 months following infection, and association was mainly driven by acute infection severity.
(© The Author(s) 2024. Published by Oxford University Press on behalf of the European Public Health Association.)
Methods: Population-based, retrospective, multi-center cohort study that analyzed hospital admissions and utilization of outpatient visits and diagnostic tests between adults aged 40 years and older recovered from SARS-CoV-2 infection occurred between February 2020 and December 2021 and matched unexposed individuals during a 6-month observation period. Healthcare utilization was analyzed by considering the setting of care for acute SARS-CoV-2 infection [non-hospitalized, hospitalized and intensive care unit (ICU)-admitted] as a proxy for the severity of acute infection and epidemic phases characterized by different SARS-CoV-2 variants. Data were retrieved from regional health administrative databases of three Italian Regions.
Results: The final cohort consisted of 307 994 previously SARS-CoV-2 infected matched with 307 994 uninfected individuals. Among exposed individuals, 92.2% were not hospitalized during the acute infection, 7.3% were hospitalized in a non-ICU ward and 0.5% were admitted to ICU. Individuals previously infected with SARS-CoV-2 (vs. unexposed), especially those hospitalized or admitted to ICU, reported higher utilization of outpatient visits (range of pooled Incidence Rate Ratios across phases; non-hospitalized: 1.11-1.33, hospitalized: 1.93-2.19, ICU-admitted: 3.01-3.40), diagnostic tests (non-hospitalized: 1.35-1.84, hospitalized: 2.86-3.43, ICU-admitted: 4.72-7.03) and hospitalizations (non-hospitalized: 1.00-1.52, hospitalized: 1.87-2.36, ICU-admitted: 4.69-5.38).
Conclusions: This study found that SARS-CoV-2 infection was associated with increased use of health care in the 6 months following infection, and association was mainly driven by acute infection severity.
(© The Author(s) 2024. Published by Oxford University Press on behalf of the European Public Health Association.)