학술논문
Cognitively defined Alzheimer's dementia subgroups have distinct atrophy patterns.
Document Type
Academic Journal
Author
Crane PK; Department of Medicine, University of Washington, Seattle, Washington, USA.; Groot C; Clinical Memory Research Unit, Lund University, Lund, Sweden.; Alzheimer center, Amsterdam UMC - VU Medical Center, Amsterdam, Netherlands.; Ossenkoppele R; Clinical Memory Research Unit, Lund University, Lund, Sweden.; Alzheimer center, Amsterdam UMC - VU Medical Center, Amsterdam, Netherlands.; Mukherjee S; Department of Medicine, University of Washington, Seattle, Washington, USA.; Choi SE; Department of Medicine, University of Washington, Seattle, Washington, USA.; Lee M; Department of Medicine, University of Washington, Seattle, Washington, USA.; Scollard P; Department of Medicine, University of Washington, Seattle, Washington, USA.; Gibbons LE; Department of Medicine, University of Washington, Seattle, Washington, USA.; Sanders RE; Department of Medicine, University of Washington, Seattle, Washington, USA.; Trittschuh E; Department of Psychiatry and Behavioral Sciences, University of Washington, and Geriatrics Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, USA.; Saykin AJ; Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, USA.; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, USA.; Mez J; Department of Neurology, Boston University, Boston, Massachusetts, USA.; Nakano C; Department of Medicine, University of Washington, Seattle, Washington, USA.; Donald CM; Department of Neurosurgery, University of Washington, Seattle, USA.; Sohi H; Department of Biomedical Informatics and Medical Education, University of Washington, Seattle, USA.; Now Pacific Northwest National Laboratory, Richland, USA.; Risacher S; Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, USA.; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, USA.
Source
Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE
Subject
Language
English
Abstract
Introduction: We sought to determine structural magnetic resonance imaging (MRI) characteristics across subgroups defined based on relative cognitive domain impairments using data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) and to compare cognitively defined to imaging-defined subgroups.
Methods: We used data from 584 people with Alzheimer's disease (AD) (461 amyloid positive, 123 unknown amyloid status) and 118 amyloid-negative controls. We used voxel-based morphometry to compare gray matter volume (GMV) for each group compared to controls and to AD-Memory.
Results: There was pronounced bilateral lower medial temporal lobe atrophy with relative cortical sparing for AD-Memory, lower left hemisphere GMV for AD-Language, anterior lower GMV for AD-Executive, and posterior lower GMV for AD-Visuospatial. Formal asymmetry comparisons showed substantially more asymmetry in the AD-Language group than any other group (p = 1.15 × 10-10 ). For overlap between imaging-defined and cognitively defined subgroups, AD-Memory matched up with an imaging-defined limbic predominant group.
Discussion: MRI findings differ across cognitively defined AD subgroups.
(© 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)
Methods: We used data from 584 people with Alzheimer's disease (AD) (461 amyloid positive, 123 unknown amyloid status) and 118 amyloid-negative controls. We used voxel-based morphometry to compare gray matter volume (GMV) for each group compared to controls and to AD-Memory.
Results: There was pronounced bilateral lower medial temporal lobe atrophy with relative cortical sparing for AD-Memory, lower left hemisphere GMV for AD-Language, anterior lower GMV for AD-Executive, and posterior lower GMV for AD-Visuospatial. Formal asymmetry comparisons showed substantially more asymmetry in the AD-Language group than any other group (p = 1.15 × 10
Discussion: MRI findings differ across cognitively defined AD subgroups.
(© 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)